Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6514444 | 0.74 | HPGD (0.42) | ESR1KMT2AMAPTKDM4EHTT | |
| SCHEMBL6514441 | 0.70 | BCHE (0.39) | ESR1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL6515011 | 0.69 | HDAC1 (0.52) | HTTL3MBTL1MAOBCYP2D6 | |
| SCHEMBL385603 | 0.66 | KMT2A (0.66) | ESR1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL6531317 | 0.66 | MAOB (0.43) | ESR1KMT2AMEN1KDM4EHTT | |
| SCHEMBL4218446 | 0.66 | ALDH1A1 (0.57) | KMT2AMEN1MAPTLMNAGAA | |
| SCHEMBL6507970 | 0.65 | HDAC1 (0.52) | KDM4EHTTL3MBTL1MAOBKCNH2 | |
| SCHEMBL975603 | 0.65 | ALDH1A1 (0.48) | KMT2AMEN1MAPTKDM4EHTT | |
| SCHEMBL12610941 | 0.65 | CYP2D6 (0.74) | ESR1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL1405290 | 0.65 | CYP2D6 (0.74) | ESR1KMT2AMEN1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005014588-A1 | SUBSTITUTED THIENYL-HYDROXAMIC ACIDS HAVING HISTONE DEACETYLASE ACTIVITY | ARGENTA DISCOVERY LIMITED (GB) | 2005-02-17 | — | — | WO | disclosed |