Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2551774 | 0.82 | TAAR1 (0.42) | KDM4EPOLBLMNAHPGDTAAR1 | |
| SCHEMBL21462756 | 0.81 | TAAR1 (0.38) | KDM4EPOLBTAAR1ALDH1A1GAA | |
| SCHEMBL2199784 | 0.74 | TAAR1 (0.63) | KDM4ETAAR1GAASMN1; SMN2 | |
| SCHEMBL6518274 | 0.74 | EED (0.36) | KDM4EPOLBLMNAHPGDTAAR1 | |
| SCHEMBL6284488 | 0.71 | STIM1 (0.39) | KDM4EPOLBTAAR1SMN1; SMN2 | |
| SCHEMBL9627 | 0.70 | ACHE (0.39) | ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL29257739 | 0.69 | ACHE (0.44) | KDM4ELMNAHPGDTAAR1ALDH1A1 | |
| SCHEMBL249134 | 0.69 | TAAR1 (0.45) | KDM4EPOLBLMNAHPGDTAAR1 | |
| SCHEMBL3196068 | 0.68 | LIPG (0.35) | KDM4ELIPGLMNAHPGDALDH1A1 | |
| SCHEMBL29399046 | 0.68 | CES2 (0.43) | HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1565452-A2 | 3-SUBSTITUTED-6-ARYL PYRIDINES AS LIGANDS OF C5A RECEPTORS | NEUROGEN CORPORATION (US) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004043925-A2 | 3-SUBSTITUTED-6-ARYL PYRIDINED AS LIGANDS OF C5A RECEPTORS | NEUROGEN CORPORATION (US) | 2004-05-27 | — | — | WO | disclosed |