Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.43 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3072202 | 0.81 | CYP2C9 (0.59) | EPHX2KMT2AGAAEPHX1ALDH1A1 | |
| SCHEMBL11304140 | 0.78 | CYP2C9 (0.54) | EPHX2FAAHFPR2GAAEPHX1 | |
| SCHEMBL16711884 | 0.78 | SMN1; SMN2 (0.58) | EPHX2 | |
| SCHEMBL15646890 | 0.77 | EPHX2 (0.50) | EPHX2KMT2ATRPV1AURKATPX2 | |
| SCHEMBL14763132 | 0.76 | LMNA (0.50) | EPHX2KMT2AAURKATPX2FAAH | |
| SCHEMBL10992464 | 0.75 | AKR1C2 (0.54) | EPHX2KMT2AAURKATPX2EPHX1 | |
| SCHEMBL16711897 | 0.75 | PPARG (0.46) | EPHX2AURKATPX2 | |
| SCHEMBL5641484 | 0.75 | EPHX1 (0.46) | EPHX2KMT2AGRIK1GRIK2FPR2 | |
| SCHEMBL2560281 | 0.74 | LDHA (0.65) | LDHAGAA | |
| SCHEMBL7470489 | 0.74 | EPHX2 (0.47) | EPHX2KMT2AAURKATPX2FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005123714-A1 | QUINAZOLINE COMPOUNDS AND THEIR USE IN MCH-RELATED DISEASE | 7TM PHARMA A/S (DK) | 2005-12-29 | — | — | WO | disclosed |