Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.70 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 11/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 10/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14973431 | 0.84 | HCAR3 (0.47) | HCAR3DEGS1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL28102450 | 0.84 | HCAR3 (0.72) | HCAR3DEGS1RAB9AKMT2AKDM4E | |
| SCHEMBL2664544 | 0.83 | HCAR3 (1.00) | HCAR3DEGS1RAB9AKMT2AKDM4E | |
| SCHEMBL1792974 | 0.81 | GCK (0.78) | KMT2AMEN1 | |
| SCHEMBL11308749 | 0.80 | HCAR3 (0.77) | HCAR3DEGS1RAB9AKMT2AKDM4E | |
| SCHEMBL4409319 | 0.80 | PTK2 (0.54) | HCAR3RAB9AKMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL26986641 | 0.79 | GRM5 (0.52) | HCAR3DEGS1RAB9AKMT2ANPC1 | |
| SCHEMBL1558817 | 0.78 | RAB9A (0.79) | HCAR3DEGS1RAB9AKMT2AKDM4E | |
| SCHEMBL31241065 | 0.78 | RAB9A (0.79) | HCAR3DEGS1RAB9AKMT2AKDM4E | |
| SCHEMBL2664558 | 0.78 | HCAR3 (0.68) | HCAR3DEGS1RAB9AKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1568367-A1 | Compounds effecting glucokinase | AstraZeneca AB (SE) | 2005-08-31 | — | — | EP | disclosed |
| EP-1529530-A1 | Compounds affecting glucokinase | AstraZeneca AB (SE) | 2005-05-11 | — | — | EP | disclosed |