Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 14/20 | 0.32 |
| ▸ | TUBB4A | P04350 | 13/20 | 0.32 |
| ▸ | TUBB | P07437 | 13/20 | 0.32 |
| ▸ | TUBA3C | P0DPH7 | 13/20 | 0.32 |
| ▸ | TUBA1B | P68363 | 13/20 | 0.32 |
| ▸ | TUBA4A | P68366 | 13/20 | 0.32 |
| ▸ | TUBB4B | P68371 | 13/20 | 0.32 |
| ▸ | TUBB3 | Q13509 | 13/20 | 0.32 |
| ▸ | TUBB2A | Q13885 | 13/20 | 0.32 |
| ▸ | TUBB8 | Q3ZCM7 | 13/20 | 0.32 |
| ▸ | TUBA3E | Q6PEY2 | 13/20 | 0.32 |
| ▸ | TUBA1A | Q71U36 | 13/20 | 0.32 |
| ▸ | TUBA1C | Q9BQE3 | 13/20 | 0.32 |
| ▸ | TUBB6 | Q9BUF5 | 13/20 | 0.32 |
| ▸ | TUBB2B | Q9BVA1 | 13/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | PLAU | P00749 | 1/20 | 0.31 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6520485 | 0.83 | TYMP (0.32) | P2RY6 | |
| SCHEMBL6521224 | 0.79 | P2RY6 (0.30) | P2RY6 | |
| SCHEMBL30388452 | 0.72 | DUT (0.32) | P2RY6 | |
| SCHEMBL6752234 | 0.72 | ALDH1A1 (0.35) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL6530739 | 0.71 | SLC28A1 (0.35) | ALDH1A1P2RY6 | |
| SCHEMBL10656146 | 0.70 | P2RY6 (0.33) | P2RY6 | |
| SCHEMBL346518 | 0.70 | CRBN (0.37) | P2RY6 | |
| SCHEMBL28431313 | 0.68 | SLC28A1 (0.35) | P2RY6 | |
| SCHEMBL29291814 | 0.66 | P2RY6 (0.37) | P2RY6 | |
| SCHEMBL98410 | 0.66 | SLC28A1 (0.49) | P2RY6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050123533-A1 | Prodrugs activated by targeted catalytic proteins | WELLSTAT BIOCATALYSIS, LLC | 2005-06-09 | — | — | US | disclosed |
| US-20030096765-A1 | Prodrugs activated by targeted catalytic proteins | IGEN, INC. | 2003-05-22 | — | — | US | disclosed |
| US-6258360-B1 | BENZOATE CONJUGATES; ANTITUMOR AGENTS | IGEN INTERNATIONAL, INC. | 2001-07-10 | — | — | US | disclosed |
| EP-0746336-A1 | PRODRUGS ACTIVATED BY TARGETED CATALYTIC PROTEINS | IGEN, INC. (US) | 1996-12-11 | — | — | EP | disclosed |
| EP-0746336-A4 | PRODRUGS ACTIVATED BY TARGETED CATALYTIC PROTEINS | IGEN INC (US) | 1996-07-26 | — | — | EP | disclosed |
| WO-1993002703-A1 | PRODRUGS ACTIVATED BY TARGETED CATALYTIC PROTEINS | IGEN, INC. (US) | 1993-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050123533-A1 | Prodrugs activated by targeted catalytic proteins | DNPH1, DNPEP, PNP | TUBB1 4366/4885TUBB4A 4389/4885TUBB 4557/4885 |
| US-20030096765-A1 | Prodrugs activated by targeted catalytic proteins | DNPH1, DNPEP, PNP | TUBB1 4366/4885TUBB4A 4389/4885TUBB 4557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.