Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Doxribtimine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.62 |
| ▸ | MTOR | P42345 | 1/20 | 0.62 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.62 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.62 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.62 |
| ▸ | P2RY2 | P41231 | 3/20 | 0.54 |
| ▸ | P2RY4 | P51582 | 3/20 | 0.54 |
| ▸ | P2RY6 | Q15077 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TK1 | P04183 | 1/20 | 0.50 |
| ▸ | DTYMK | P23919 | 2/20 | 0.49 |
| ▸ | TK2 | O00142 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Doxribtimine SCHEMBL787714 | 1.00 | LMNA (0.62) | LMNATHRBMTORMDM2NCOA1 | |
| Doxribtimine SCHEMBL29124320 | 0.96 | P2RY2 (0.60) | LMNATHRBMTORMDM2NCOA1 | |
| Doxribtimine SCHEMBL3951759 | 0.92 | TK1 (0.56) | LMNASMN1; SMN2TK1TK2 | |
| Cytidine SCHEMBL4468985 | 0.90 | LMNA (0.65) | LMNATHRBMTORMDM2NCOA1 | |
| Adenosine SCHEMBL23835231 | 0.89 | DTYMK (0.66) | SMN1; SMN2DTYMK | |
| Cytidine SCHEMBL574775 | 0.88 | LMNA (0.62) | LMNATHRBMTORMDM2NCOA1 | |
| Guanosine SCHEMBL10528215 | 0.87 | F2 (0.64) | LMNATHRBMTORMDM2NCOA1 | |
| Cytidine SCHEMBL574822 | 0.87 | LMNA (0.67) | LMNATHRBMTORMDM2NCOA1 | |
| Doxecitine SCHEMBL9803658 | 0.87 | LMNA (0.50) | LMNASMN1; SMN2TK1TK2 | |
| Doxribtimine SCHEMBL325199 | 0.87 | TK1 (0.62) | LMNASMN1; SMN2TK1TK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6955915-B2 | Apparatus comprising polymers | AFFYMETRIX, INC. (US) | 2005-10-18 | — | — | US | disclosed |
| US-20050208537-A1 | Very large scale immobilized polymer synthesis | AFFYMETRIX, INC. (US) | 2005-09-22 | — | — | US | disclosed |
| US-20050095652-A1 | Apparatus comprising polymers | AFFYMETRIX, INC. (US) | 2005-05-05 | — | — | US | disclosed |
| US-20050079529-A1 | Very large scale immobilized polymer synthesis | AFFYMETRIX, INC. (US) | 2005-04-14 | — | — | US | disclosed |
| EP-1046421-B1 | Methods and reagents for very large scale immobilized polymer synthesis | AFFYMETRIX INC (US) | 2003-07-02 | — | — | EP | disclosed |
| US-20030108899-A1 | Very large scale immobilized polymer synthesis | AFFYMETRIX, INC. (US) | 2003-06-12 | — | — | US | disclosed |
| US-6506558-B1 | Deprotecting nucleoside, nucleotide or amino acid to form polypeptide or polynucleotide | AFFYMETRIX INC. | 2003-01-14 | — | — | US | disclosed |
| US-20020137096-A1 | Apparatus comprising polymers | AFFYMETRIX, INC. (US) | 2002-09-26 | — | — | US | disclosed |
| US-6420169-B1 | Apparatus for forming polynucleotides or polypeptides | AFFYMETRIX, INC. | 2002-07-16 | — | — | US | disclosed |
| EP-0562025-B1 | Compounds and their use in a binary synthesis strategy | AFFYMETRIX INC (US) | 2001-02-07 | — | — | EP | disclosed |
| EP-1046421-A2 | Methods and reagents for very large scale immobilized polymer synthesis | Affymetrix, Inc. (US) | 2000-10-25 | — | — | EP | disclosed |
| US-5424186-A | Biosynthesis of oligonucleotides on solid substrate by irradiation of predefined segments to remove blocking agents; then coupling with nucleotide | AFFYMAX TECHNOLOGIES N.V. (AN) | 1995-06-13 | — | — | US | disclosed |
| EP-0562025-A4 | — | — | 1994-03-30 | — | — | EP | disclosed |
| EP-0562025-A1 | VERY LARGE SCALE IMMOBILIZED POLYMER SYNTHESIS | AFFYMAX TECHNOLOGIES N.V. (AN) | 1993-09-29 | — | — | EP | disclosed |
| WO-1992010092-A1 | VERY LARGE SCALE IMMOBILIZED POLYMER SYNTHESIS | AFFYMAX TECHNOLOGIES N.V. (AN) | 1992-06-25 | — | — | WO | disclosed |