Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | TYMS | P04818 | 2/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | MLKL | Q8NB16 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6514887 | 0.81 | CYP1A2 (0.44) | CYP1A2ALDH1A1ALOX15KMT2AHTT | |
| SCHEMBL14643309 | 0.78 | MLKL (0.41) | CYP1A2ALDH1A1ALOX15KMT2AHTT | |
| SCHEMBL10644678 | 0.74 | TYMS (0.60) | CYP1A2ALDH1A1HTTTYMSKIF11 | |
| SCHEMBL6515025 | 0.73 | CYP1A2 (0.53) | CYP1A2ALDH1A1ALOX15KMT2AHTT | |
| SCHEMBL6516334 | 0.72 | CYP1A2 (0.47) | CYP1A2ALDH1A1ALOX15KMT2AHTT | |
| SCHEMBL17153975 | 0.70 | KIF11 (0.44) | ALDH1A1KMT2AHTTMEN1TYMS | |
| SCHEMBL2673705 | 0.70 | IDO1 (0.72) | CYP1A2ALDH1A1ALOX15KMT2AHTT | |
| SCHEMBL2674618 | 0.70 | IDO1 (0.72) | CYP1A2ALDH1A1ALOX15KMT2AHTT | |
| SCHEMBL29537224 | 0.70 | IDO1 (0.72) | CYP1A2ALDH1A1ALOX15KMT2AHTT | |
| SCHEMBL250817 | 0.70 | IDO1 (0.72) | CYP1A2ALDH1A1ALOX15KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050148643-A1 | Carbamate compositions and methods fo rmodulating the activity of the CHK1 enzyme | AGOURON PHARMACEUTICALS, INC. | 2005-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050148643-A1 | Carbamate compositions and methods fo rmodulating the activity of the CHK1 enzyme | CHEK1, CHEK2, RAD1 | CYP1A2 3569/4885ALDH1A1 2713/4885ALOX15 1939/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.