SCHEMBL6520111

SCHEMBL6520111

COc1ccc(-c2nc(-c3ccc(OC)cc3)nc(-c3cccc(O)c3O)n2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 6/20 0.48
RAB9A P51151 3/20 0.48
KDM4E B2RXH2 3/20 0.46
HDAC4 P56524 2/20 0.46
HDAC2 Q92769 2/20 0.46
HDAC8 Q9BY41 2/20 0.46
ALDH1A1 P00352 2/20 0.46
HPGD P15428 2/20 0.46
CLK4 Q9HAZ1 1/20 0.46
MEN1 O00255 5/20 0.45
KMT2A Q03164 5/20 0.45
RELA Q04206 3/20 0.45
LMNA P02545 3/20 0.45
ALOX15 P16050 3/20 0.45
NFKB1 P19838 2/20 0.45
NFKB2 Q00653 2/20 0.45
ALOX12 P18054 2/20 0.45
MAPT P10636 6/20 0.44
TP53 P04637 3/20 0.44
SMN1; SMN2 Q16637 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15909996 0.87 NPC1 (0.57) NPC1RAB9AKDM4EHDAC4HDAC2
SCHEMBL6512448 0.87 NPC1 (0.57) NPC1RAB9AKDM4EHDAC4HDAC2
SCHEMBL16746693 0.87 NPC1 (0.57) NPC1RAB9AKDM4EHDAC4HDAC2
SCHEMBL6509217 0.86 NR1H4 (0.49) NPC1RAB9AKDM4EHDAC4HDAC2
SCHEMBL12216378 0.86 MEN1 (0.56) NPC1RAB9AKDM4EHDAC4HDAC2
SCHEMBL39029 0.84 ALOX15 (0.62) NPC1RAB9AKDM4EALDH1A1HPGD
SCHEMBL29364346 0.84 ALOX15 (0.62) NPC1RAB9AKDM4EALDH1A1HPGD
SCHEMBL25041862 0.83 HDAC4 (0.64) NPC1RAB9AKDM4EHDAC4HDAC2
SCHEMBL30237983 0.83 HDAC4 (0.64) NPC1RAB9AKDM4EHDAC4HDAC2
SCHEMBL4027746 0.83 ALOX15 (0.60) NPC1RAB9AKDM4EHDAC4HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0834304-B1 Use of liposomogenic UV absorbers to protect hair CIBA SC HOLDING AG (CH) 2005-01-26 EP disclosed
EP-0815071-B1 LIPOSOMOGENIC UV ABSORBERS CIBA SC HOLDING AG (CH) 2001-04-11 EP disclosed
US-6017556-A PROTECTING HUMAN HAIR FROM THE DAMAGING EFFECT OF ULTRAVIOLET RADIATION BY TREATING HUMAN HAIR WITH A LIPOSOMOGENIC ULTRAVIOLET RADIATION ABSORBER CIBA SPECIALTY CHEMICALS CORPORATION (US) 2000-01-25 US disclosed
US-6015575-A TRIAZINE, BENZOTRIAZOLE, BENZOPHENONE AND AMINOBENZOIC ACID DERIVATIVES AS RADIATION ABSORBERS CIBA SPECIALTY CHEMICALS CORPORATION (US) 2000-01-18 US disclosed
EP-0834304-A2 Liposomogenic UV absorbers Ciba SC Holding AG (CH) 1998-04-08 EP disclosed
US-5688995-A SUNSCREEN AGENTS CIBA-GEIGY CORPORATION (US) 1997-11-18 US disclosed
US-5591850-A STABILIZERS FOR TEXTILE FIBERS, COSMETIC SUNSCREENS CIBA-GEIGY CORPORATION (US) 1997-01-07 US disclosed
EP-0743309-A1 o-Hydroxyphenyl-s-triazines as UV stabilisers CIBA-GEIGY AG (CH) 1996-11-20 EP disclosed
EP-0654469-A1 O-Hydroxyphenyl-s-triazines as stabilisers for polymers CIBA-GEIGY AG (CH) 1995-05-24 EP disclosed