SCHEMBL6509217

SCHEMBL6509217

COc1ccc(-c2nc(-c3ccc(OC)cc3)nc(-c3cccc(C)c3O)n2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR1H4 Q96RI1 2/20 0.49
HDAC4 P56524 1/20 0.45
HDAC2 Q92769 1/20 0.45
HDAC8 Q9BY41 1/20 0.45
CLK4 Q9HAZ1 1/20 0.45
MAPT P10636 7/20 0.43
TP53 P04637 3/20 0.43
SMN1; SMN2 Q16637 3/20 0.43
LMNA P02545 1/20 0.43
NPC1 O15118 5/20 0.42
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
BACE1 P56817 1/20 0.42
RAB9A P51151 3/20 0.42
NFKB1 P19838 1/20 0.42
NFKB2 Q00653 1/20 0.42
RELA Q04206 1/20 0.42
KDM4E B2RXH2 2/20 0.41
ALDH1A1 P00352 1/20 0.41
HPGD P15428 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13299329 0.96 NPC1 (0.47) NR1H4HDAC4HDAC2HDAC8CLK4
SCHEMBL16790613 0.90 ALDH1A1 (0.46) NR1H4HDAC4HDAC2HDAC8CLK4
SCHEMBL6520111 0.86 NPC1 (0.48) HDAC4HDAC2HDAC8CLK4MAPT
SCHEMBL12216378 0.85 MEN1 (0.56) HDAC4HDAC2HDAC8CLK4MAPT
SCHEMBL18780272 0.84 ALDH1A1 (0.43) MAPTTP53SMN1; SMN2LMNANPC1
SCHEMBL13299334 0.83 MEN1 (0.52) HDAC4HDAC2HDAC8MAPTTP53
SCHEMBL13299331 0.82 NR1H4 (0.57) NR1H4HDAC4HDAC2HDAC8MAPT
SCHEMBL22100520 0.82 L3MBTL1 (0.52) NR1H4CLK4MAPTSMN1; SMN2LMNA
SCHEMBL12714311 0.82 ALDH1A1 (0.56) MAPTSMN1; SMN2NPC1KMT2ANFKB1
SCHEMBL16746693 0.80 NPC1 (0.57) NR1H4HDAC4HDAC2HDAC8CLK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170189277-A1 COMPOSITE PIGMENT AND METHOD FOR PREPARATION THEREOF L'OREAL (FR) 2017-07-06 US disclosed
US-9669243-B2 Delivery of hydrophobic benefit agents from bodywashes and the like onto a keratinous substrate BASF SE (DE) 2017-06-06 US disclosed
US-20150190320-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE SUNSCREEN PARTICLES L'OREAL (FR) 2015-07-09 US disclosed
US-20150190320-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE SUNSCREEN PARTICLES L'OREAL (FR) 2015-07-09 US disclosed
US-20150157539-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE PARTICLES L'OREAL (FR) 2015-06-11 US disclosed
US-8882902-B2 Composite pigment and method for preparation thereof L'OREAL (FR) 2014-11-11 US disclosed
US-8882902-B2 Composite pigment and method for preparation thereof L'OREAL (FR) 2014-11-11 US disclosed
US-20130309285-A1 COMPOSITE PIGMENT AND METHOD FOR PREPARATION THEREOF L'OREAL (FR) 2013-11-21 US disclosed
US-20130259912-A1 COMPOSITE PIGMENT AND METHOD FOR PREPARATION THEREOF L'OREAL (FR) 2013-10-03 US disclosed
US-20130259912-A1 COMPOSITE PIGMENT AND METHOD FOR PREPARATION THEREOF L'OREAL (FR) 2013-10-03 US disclosed
EP-1213013-B1 Process for preparing solid compositions of water-soluble, hardly water-soluble or water-insoluble active agents BASF AG (DE) 2007-04-04 EP disclosed
EP-0834304-B1 Use of liposomogenic UV absorbers to protect hair CIBA SC HOLDING AG (CH) 2005-01-26 EP disclosed
EP-0815071-B1 LIPOSOMOGENIC UV ABSORBERS CIBA SC HOLDING AG (CH) 2001-04-11 EP disclosed
US-6017556-A PROTECTING HUMAN HAIR FROM THE DAMAGING EFFECT OF ULTRAVIOLET RADIATION BY TREATING HUMAN HAIR WITH A LIPOSOMOGENIC ULTRAVIOLET RADIATION ABSORBER CIBA SPECIALTY CHEMICALS CORPORATION (US) 2000-01-25 US disclosed
US-6015575-A TRIAZINE, BENZOTRIAZOLE, BENZOPHENONE AND AMINOBENZOIC ACID DERIVATIVES AS RADIATION ABSORBERS CIBA SPECIALTY CHEMICALS CORPORATION (US) 2000-01-18 US disclosed
EP-0834304-A2 Liposomogenic UV absorbers Ciba SC Holding AG (CH) 1998-04-08 EP disclosed
US-5688995-A SUNSCREEN AGENTS CIBA-GEIGY CORPORATION (US) 1997-11-18 US disclosed
US-5591850-A STABILIZERS FOR TEXTILE FIBERS, COSMETIC SUNSCREENS CIBA-GEIGY CORPORATION (US) 1997-01-07 US disclosed
EP-0743309-A1 o-Hydroxyphenyl-s-triazines as UV stabilisers CIBA-GEIGY AG (CH) 1996-11-20 EP disclosed
EP-0654469-A1 O-Hydroxyphenyl-s-triazines as stabilisers for polymers CIBA-GEIGY AG (CH) 1995-05-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170189277-A1 COMPOSITE PIGMENT AND METHOD FOR PREPARATION THEREOF TYR, RAB5IF, MITF NR1H4 4668/4885HDAC4 1731/4885HDAC2 1978/4885
US-20130259912-A1 COMPOSITE PIGMENT AND METHOD FOR PREPARATION THEREOF TYR, MITF, PUF60 NR1H4 4638/4885HDAC4 1488/4885HDAC2 1968/4885
US-20150157539-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE PARTICLES MITF, RAB5IF, TYR NR1H4 4613/4885HDAC4 951/4885HDAC2 551/4885
US-20130309285-A1 COMPOSITE PIGMENT AND METHOD FOR PREPARATION THEREOF TYR, RAB5IF, MITF NR1H4 4668/4885HDAC4 1731/4885HDAC2 1978/4885
US-20150190320-A1 COSMETIC COMPOSITION COMPRISING COMPOSITE SUNSCREEN PARTICLES XPA, ERCC1, ERCC4 NR1H4 3874/4885HDAC4 1478/4885HDAC2 624/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.