Sugi Predict

Sugi Predict / Compounds / SCHEMBL6520541

SCHEMBL6520541

SCHEMBL6520541

Cc1c(-c2ccc(Cl)cc2)nc2ccc(-c3ccc(F)c(CO)c3F)cn12

nearest known ligand 0.61

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ NR4A2 P43354 2/20 0.61
▸ ALDH1A1 P00352 2/20 0.40
▸ MAPT P10636 4/20 0.40
▸ TP53 P04637 3/20 0.40
▸ GAA P10253 3/20 0.40
▸ NR1H4 Q96RI1 1/20 0.40
▸ SLC2A2 P11168 2/20 0.39
▸ SLC2A1 P11166 3/20 0.39
▸ TOP2A P11388 1/20 0.39
▸ POLB P06746 1/20 0.39
▸ CYP1A2 P05177 1/20 0.38
▸ CYP2C9 P11712 1/20 0.38
▸ CYP2C19 P33261 1/20 0.38
▸ SLC2A3 P11169 1/20 0.38
▸ SLC2A4 P14672 1/20 0.38
▸ MEN1 O00255 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ CYP11B1 P15538 1/20 0.37
▸ CYP11B2 P19099 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6519571 0.91 NR4A2 (0.50) NR4A2MAPTNR1H4SLC2A2SLC2A1
SCHEMBL16208077 0.90 NR4A2 (0.65) NR4A2ALDH1A1MAPTTP53GAA
SCHEMBL6521387 0.89 NR4A2 (0.51) NR4A2MAPTNR1H4SLC2A1CYP11B1
SCHEMBL6527443 0.88 NR4A2 (0.47) NR4A2ALDH1A1MAPTGAANR1H4
SCHEMBL3431442 0.88 NR4A2 (0.47) NR4A2ALDH1A1MAPTTP53GAA
SCHEMBL3431629 0.82 NR4A2 (0.46) NR4A2TP53GAANR1H4SLC2A1
SCHEMBL6521811 0.79 TRPA1 (0.42) NR4A2MAPTTP53GAANR1H4
SCHEMBL6524183 0.79 DHODH (0.44) ALDH1A1MAPTNR1H4SLC2A2SLC2A1
SCHEMBL2064008 0.76 NR4A2 (1.00) NR4A2ALDH1A1MAPTCYP2C9
SCHEMBL6523033 0.75 CYP11B1 (0.44) ALDH1A1MAPTGAANR1H4SLC2A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2262769-B1 POLYSUBSTITUTED 2-ARYL-6-PHENYL-IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, AND PREPARATION AND THERAPEUTIC USE THEREOF SANOFI SA (FR) 2014-11-05 — — EP claimed
US-8507520-B2 Polysubstituted 2-aryl-6-phenylimidazo[1,2-A]pyridine derivatives, and preparation and therapeutic use thereof SANOFI (FR) 2013-08-13 — — US claimed
US-20110065745-A1 POLYSUBSTITUTED 2-ARYL-6-PHENYLIMIDAZO[1,2-A]PYRIDINE DERIVATIVES, AND PREPARATION AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2011-03-17 — — US claimed
EP-2262769-B1 POLYSUBSTITUTED 2-ARYL-6-PHENYL-IMIDAZO[1,2-A]PYRIDINE DERIVATIVES, AND PREPARATION AND THERAPEUTIC USE THEREOF SANOFI SA (FR) 2014-11-05 — — EP disclosed
US-20110065745-A1 POLYSUBSTITUTED 2-ARYL-6-PHENYLIMIDAZO[1,2-A]PYRIDINE DERIVATIVES, AND PREPARATION AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2011-03-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110065745-A1 POLYSUBSTITUTED 2-ARYL-6-PHENYLIMIDAZO[1,2-A]PYRIDINE DERIVATIVES, AND PREPARATION AND THERAPEUTIC USE THEREOF JAK2, ABL1, REN NR4A2 1394/4885ALDH1A1 148/4885MAPT 2633/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.