Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | GRIK1 | P39086 | 8/20 | 0.54 |
| ▸ | GRIK2 | Q13002 | 5/20 | 0.54 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.54 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.54 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.50 |
| ▸ | GGT1 | P19440 | 4/20 | 0.48 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.48 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.46 |
| ▸ | GRIK3 | Q13003 | 4/20 | 0.46 |
| ▸ | GRIK5 | Q16478 | 4/20 | 0.46 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.46 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.46 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Asparagine SCHEMBL30131205 | 1.00 | — | — | |
| Asparagine SCHEMBL8827 | 1.00 | — | — | |
| Asparagine SCHEMBL30486685 | 1.00 | — | — | |
| Asparagine SCHEMBL288093 | 1.00 | ALOX15 (0.56) | ALOX15BLMPMP22KMT2AGRIK1 | |
| Asparagine SCHEMBL4347082 | 1.00 | ALOX15 (0.56) | ALOX15BLMPMP22KMT2AGRIK1 | |
| Asparagine SCHEMBL15460 | 1.00 | ALOX15 (0.56) | ALOX15BLMPMP22KMT2AGRIK1 | |
| Asparagine SCHEMBL8826 | 1.00 | — | — | |
| Asparagine SCHEMBL150535 | 1.00 | ALOX15 (0.56) | ALOX15BLMPMP22KMT2AGRIK1 | |
| Asparagine SCHEMBL20489207 | 1.00 | ALOX15 (0.56) | ALOX15BLMPMP22KMT2AGRIK1 | |
| Asparagine SCHEMBL30610983 | 1.00 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110002983-A1 | COMPOUND | IMUTHES LIMITED (GB) | 2011-01-06 | — | — | US | claimed |
| US-10273267-B2 | Beta-hairpin peptidomimetics as selective elastase inhibitors | POLYPHOR AG (CH) | 2019-04-30 | — | — | US | disclosed |
| US-20160333053-A1 | BETA-HAIRPIN PEPTIDOMIMETICS AS SELECTIVE ELASTASE INHIBITORS | POLYPHOR AG (CH) | 2016-11-17 | — | — | US | disclosed |
| EP-3087094-A1 | BETA-HAIRPIN PEPTIDOMIMETICS AS SELECTIVE ELASTASE INHIBITORS | Polyphor AG (CH) | 2016-11-02 | — | — | EP | disclosed |
| US-9284352-B2 | Beta-hairpin peptidomimetics having CXCR4 antagonizing activity | POLYPHOR AG (CH) | 2016-03-15 | — | — | US | disclosed |
| WO-2015096873-A1 | BETA-HAIRPIN PEPTIDOMIMETICS AS SELECTIVE ELASTASE INHIBITORS | POLYPHOR AG (CH) | 2015-07-02 | — | — | WO | disclosed |
| US-20140364583-A1 | BETA-HAIRPIN PEPTIDOMIMETICS HAVING CXCR4 ANTAGONIZING ACTIVITY | POLYPHOR AG (CH) | 2014-12-11 | — | — | US | disclosed |
| US-8865656-B2 | Beta-hairpin peptidomimetics having CXCR4 antagonizing activity | POLYPHOR AG (CH) | 2014-10-21 | — | — | US | disclosed |
| US-8716242-B2 | β-hairpin peptidomimetics | POLYPHOR AG (CH) | 2014-05-06 | — | — | US | disclosed |
| US-20120283196-A1 | BETA-HAIRPIN PEPTIDOMIMETICS | POLYPHOR AG (CH) | 2012-11-08 | — | — | US | disclosed |
| US-20120135942-A1 | BETA-HAIRPIN PEPTIDOMIMETICS | POLYPHOR AG (CH) | 2012-05-31 | — | — | US | disclosed |
| EP-2427476-A1 | BETA-HAIRPIN PEPTIDOMIMETICS HAVING CXCR4 ANTAGONIZING ACTIVITY | Polyphor Ag (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2011066869-A1 | BETA-HAIRPIN PEPTIDOMIMETICS | POLYPHOR AG (CH) | 2011-06-09 | — | — | WO | disclosed |
| US-20110002983-A1 | COMPOUND | IMUTHES LIMITED (GB) | 2011-01-06 | — | — | US | disclosed |
| WO-2010127704-A1 | BETA-HAIRPIN PEPTIDOMIMETICS HAVING CXCR4 ANTAGONIZING ACTIVITY | POLYPHOR AG (CH) | 2010-11-11 | — | — | WO | disclosed |
| WO-2008077194-A1 | RECEPTOR AGONISTS | XENOME LTD (AU) | 2008-07-03 | — | — | WO | disclosed |
| WO-2005051367-A1 | CARBOXAMIDE AND AMINO DERIVATIVES AND METHODS OF THEIR USE | ADOLOR CORPORATION (US) | 2005-06-09 | — | — | WO | disclosed |
| US-20050113294-A1 | In certain embodiments, the carboxamide and amino derivatives are ligands of the delta opioid receptor and are useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other delta opioid receptor-mediated conditions | ADOLOR CORPORATION. | 2005-05-26 | — | — | US | disclosed |
| US-20050113295-A1 | Carboxamide and amino derivatives and methods of their use | ADOLOR CORPORATION | 2005-05-26 | — | — | US | disclosed |
| US-4473646-A | SEPARATION OF ISOMERS, PURIFICATION | DEVELOPMENT FINANCE CORP. OF NEW ZEALAND (NZ) | 1984-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120135942-A1 | BETA-HAIRPIN PEPTIDOMIMETICS | CXCR4, CXCL12, CXCR6 | ALOX15 3901/4885BLM 3812/4885PMP22 2080/4885 |
| US-20160333053-A1 | BETA-HAIRPIN PEPTIDOMIMETICS AS SELECTIVE ELASTASE INHIBITORS | SERPINB1, ELANE, XPNPEP1 | ALOX15 1202/4885BLM 2812/4885PMP22 2897/4885 |
| US-20120283196-A1 | BETA-HAIRPIN PEPTIDOMIMETICS | CXCL12, CXCR4, CXCR1 | ALOX15 3809/4885BLM 2925/4885PMP22 1616/4885 |
| US-20050113294-A1 | In certain embodiments, the carboxamide and amino derivatives are ligands of the delta opioid receptor and are useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other delta opioid receptor-mediated conditions | OPRD1, OPRK1, OPRL1 | ALOX15 1988/4885BLM 4845/4885PMP22 2514/4885 |
| US-10273267-B2 | Beta-hairpin peptidomimetics as selective elastase inhibitors | SERPINB1, ELANE, XPNPEP1 | ALOX15 1202/4885BLM 2812/4885PMP22 2897/4885 |
| US-20050113295-A1 | Carboxamide and amino derivatives and methods of their use | OPRK1, OPRD1, OPRL1 | ALOX15 2188/4885BLM 4794/4885PMP22 2925/4885 |
| US-20110002983-A1 | COMPOUND | C5AR1, C5AR2, ARG1 | ALOX15 1167/4885BLM 2442/4885PMP22 1042/4885 |
| US-20140364583-A1 | BETA-HAIRPIN PEPTIDOMIMETICS HAVING CXCR4 ANTAGONIZING ACTIVITY | CXCR4, CXCL12, CXCR1 | ALOX15 4110/4885BLM 4097/4885PMP22 2664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.