SCHEMBL6521774

SCHEMBL6521774

FC(F)C(F)(c1cccc(Cl)c1)C(F)(F)F

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.38
MEN1 O00255 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
MAPT P10636 1/20 0.38
CYP2C19 P33261 1/20 0.38
KMT2A Q03164 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
CYP19A1 P11511 2/20 0.38
KIF11 P52732 3/20 0.37
NR3C1 P04150 1/20 0.36
HSD11B1 P28845 1/20 0.35
TSHR P16473 1/20 0.34
CETP P11597 1/20 0.34
SLC6A4 P31645 3/20 0.33
HTR2C P28335 1/20 0.33
HTR2B P41595 1/20 0.33
HTR6 P50406 1/20 0.33
OPRL1 P41146 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9421398 0.86 PGK1 (0.39) ALDH1A1KIF11TSHRHTR2CHTR2B
SCHEMBL6864521 0.77 ALDH1A1 (0.38) ALDH1A1MEN1CYP1A2CYP3A4CYP2D6
SCHEMBL4814929 0.77 TSHR (0.59) ALDH1A1MEN1CYP3A4MAPTKMT2A
SCHEMBL28902267 0.77 LMNA (0.41) ALDH1A1MEN1CYP3A4MAPTKMT2A
SCHEMBL3669794 0.75 ALDH1A1 (0.42) ALDH1A1MEN1CYP1A2CYP3A4CYP2D6
SCHEMBL21636273 0.75 ALDH1A1 (0.42) ALDH1A1MEN1CYP1A2CYP3A4CYP2D6
SCHEMBL3130889 0.75 CYP19A1 (0.39) MEN1MAPTKMT2ACYP19A1HSD11B1
SCHEMBL7870019 0.74 TSHR (0.48) ALDH1A1MAPTSMN1; SMN2KIF11TSHR
SCHEMBL592796 0.74 ALDH1A1 (0.58) ALDH1A1MEN1CYP1A2CYP3A4CYP2D6
SCHEMBL29635769 0.74 ALDH1A1 (0.58) ALDH1A1MEN1CYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1245554-B1 Monomer containing electron-withdrawing group and electron-donative group, and copolymer and proton-conductive membrane comprising same JSR CORP (JP) 2005-01-26 EP disclosed