SCHEMBL3130889

SCHEMBL3130889

FC(F)C(F)(c1ccc(Cl)cc1)C(F)(F)F

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 7/20 0.39
TSHR P16473 2/20 0.38
MAPK1 P28482 2/20 0.38
HIF1A Q16665 2/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
LMNA P02545 2/20 0.36
CYP2A6 P11509 1/20 0.36
MAPT P10636 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
TP53 P04637 1/20 0.33
HPGD P15428 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
HSD11B1 P28845 1/20 0.33
P2RX3 P56373 1/20 0.33
KCNH2 Q12809 1/20 0.33
TMEM97 Q5BJF2 1/20 0.33
MIF P14174 1/20 0.32
CNR2 P34972 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7647444 0.88 ESR1 (0.35)
SCHEMBL10581035 0.79 KCNN4 (0.35) CYP19A1MAPK1HSD11B1
SCHEMBL1719753 0.77 ESR1 (0.54) TSHRHIF1AMEN1KMT2ALMNA
SCHEMBL10361813 0.77 MLYCD (0.46) CYP19A1TSHRMEN1KMT2ANPSR1
SCHEMBL28444481 0.77 TRPV4 (0.31)
SCHEMBL323077 0.77 KIF11 (0.46) TSHRMAPK1MEN1KMT2ALMNA
SCHEMBL7870019 0.76 TSHR (0.48) TSHRMAPK1LMNAMAPTNPSR1
SCHEMBL28512548 0.76 ESR1 (0.52) TSHRHIF1AMEN1KMT2ALMNA
SCHEMBL6521774 0.75 ALDH1A1 (0.38) CYP19A1TSHRMEN1KMT2AMAPT
SCHEMBL7602705 0.74 PDE2A (0.35) TSHRKMT2AHSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117304452-A Sulfonated polyphenylene ionomer, preparation method thereof and proton exchange membrane 河南大学 2023-12-29 CN disclosed
CN-114805332-A Bismaleimide containing oxazine side group and Cardo structure and preparation method thereof 大连理工大学 2022-07-29 CN disclosed
CN-112624930-A Preparation method of 2, 2-bis (4-aminophenyl) hexafluoropropane 上海如鲲新材料有限公司 2021-04-09 CN disclosed
WO-2020017113-A1 POLYMER ELECTROLYTE, METHOD FOR PRODUCING SAME, POLYMER ELECTROLYTE MEMBRANE USING SAME, CATALYST LAYER, MEMBRANE/ELECTRODE ASSEMBLY AND FUEL CELL 国立大学法人山梨大学 2020-01-23 WO disclosed
EP-1575115-B1 Polymer electrolyte and proton conductive membrane HONDA MOTOR CO LTD (JP) 2010-02-03 EP disclosed
EP-1575115-A2 Polymer electrolyte and proton conductive membrane Honda Motor Co., Ltd. (JP) 2005-09-14 EP disclosed