Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | ANPEP | P15144 | 3/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL29677148 | 0.93 | CA1 (0.51) | MAOAMAOBCA1CA2ANPEP | |
| Sulfuric Acid SCHEMBL4209900 | 0.93 | CA1 (0.51) | MAOAMAOBCA1CA2ANPEP | |
| Methylamine SCHEMBL27747656 | 0.85 | IDO1 (0.52) | PDPK1ANPEPIDO1 | |
| SCHEMBL29858363 | 0.85 | IDO1 (0.55) | PDPK1ANPEPIDO1 | |
| SCHEMBL6600 | 0.85 | IDO1 (0.55) | PDPK1ANPEPIDO1 | |
| SCHEMBL29395342 | 0.85 | IDO1 (0.55) | PDPK1ANPEPIDO1 | |
| SCHEMBL42279 | 0.85 | IDO1 (0.55) | PDPK1ANPEPIDO1 | |
| SCHEMBL12787610 | 0.85 | IDO1 (0.55) | PDPK1ANPEPIDO1 | |
| SCHEMBL28840240 | 0.85 | IDO1 (0.55) | PDPK1ANPEPIDO1 | |
| SCHEMBL42780 | 0.85 | IDO1 (0.55) | PDPK1ANPEPIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103476404-B | Transdermal composition comprising active agent layer and activating agent conversion coating | 帝国制药美国公司 | 2017-09-29 | — | — | CN | claimed |
| CN-108186611-A | Iodopropynylbutylcarbamate indane transdermal composition | 帝国制药美国公司 | 2018-06-22 | — | — | CN | disclosed |
| US-8461388-B2 | Process for the synthesis of propargylated aminoindan derivatives | CIPLA LIMITED (IN) | 2013-06-11 | — | — | US | disclosed |
| US-20110054218-A1 | Process for the Synthesis of Propargylated Aminoindan Derivatives | CIPLA LIMITED (IN) | 2011-03-03 | — | — | US | disclosed |
| EP-0858328-A4 | STABLE COMPOSITIONS CONTAINING N-PROPARGYL-1-AMINOINDAN | TEVA PHARMA (IL) | 2001-07-11 | — | — | EP | disclosed |
| EP-0858328-A2 | STABLE COMPOSITIONS CONTAINING N-PROPARGYL-1-AMINOINDAN | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997012583-A2 | STABLE COMPOSITIONS CONTAINING N-PROPARGYL-1-AMINOINDAN | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 1997-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110054218-A1 | Process for the Synthesis of Propargylated Aminoindan Derivatives | DAO, DDC, HRH2 | MAOB 549/4885MAOA 811/4885CA1 3441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.