Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 1/20 | 0.52 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 2/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.45 |
| ▸ | PI4KA | P42356 | 1/20 | 0.45 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.45 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.45 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12795885 | 0.88 | RXFP1 (0.47) | YTHDC1SMN1; SMN2RXFP1ALDH1A1 | |
| SCHEMBL16298450 | 0.85 | YTHDC1 (0.59) | YTHDC1RXFP1ADORA2AALDH1A1CYP1A2 | |
| SCHEMBL12795888 | 0.83 | YTHDC1 (0.46) | YTHDC1RXFP1 | |
| SCHEMBL16298436 | 0.80 | GAA (0.50) | BRD4ADORA2BSMN1; SMN2RXFP1ADORA2A | |
| SCHEMBL12795886 | 0.78 | BRD4 (0.44) | PDE4APDE4BPDE4CPDE4DBRD4 | |
| SCHEMBL12795890 | 0.78 | SLC29A1 (0.41) | YTHDC1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6520143 | 0.76 | CDK1 (0.45) | PNPYTHDC1CDK1PDE4APDE4B | |
| SCHEMBL2048470 | 0.75 | BRD4 (0.52) | PNPBRD4ADORA2BSMN1; SMN2RXFP1 | |
| SCHEMBL14554321 | 0.75 | CTSL (0.48) | YTHDC1ADORA2A | |
| SCHEMBL9199927 | 0.74 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8349858-B2 | Polycyclic guanine derivatives and use thereof | MERCK SHARP & DOHME (US) | 2013-01-08 | — | — | US | disclosed |
| US-8349858-B2 | Polycyclic guanine derivatives and use thereof | MERCK SHARP & DOHME (US) | 2013-01-08 | — | — | US | disclosed |
| US-8349858-B2 | Polycyclic guanine derivatives and use thereof | MERCK SHARP & DOHME (US) | 2013-01-08 | — | — | US | disclosed |
| US-20120316176-A1 | DERIVATIVES OF 7,8-DIHYDRO-1H-IMIDAZO[2,1-b] PURIN-4(5H)-ONE and METHODS OF USE THEREOF | MERCK SHARP & DOHME CORP. | 2012-12-13 | — | — | US | disclosed |
| US-20120316176-A1 | DERIVATIVES OF 7,8-DIHYDRO-1H-IMIDAZO[2,1-b] PURIN-4(5H)-ONE and METHODS OF USE THEREOF | MERCK SHARP & DOHME CORP. | 2012-12-13 | — | — | US | disclosed |
| US-20120316176-A1 | DERIVATIVES OF 7,8-DIHYDRO-1H-IMIDAZO[2,1-b] PURIN-4(5H)-ONE and METHODS OF USE THEREOF | MERCK SHARP & DOHME CORP. | 2012-12-13 | — | — | US | disclosed |
| WO-2011079000-A1 | DERIVATIVES OF 7,8-DIHYDRO-1H-IMIDAZO[2,1-b]PURIN-4(5H)-ONE AND METHODS OF USE THEREOF | SCHERING CORPORATION (US) | 2011-06-30 | — | — | WO | disclosed |
| US-20110065738-A1 | POLYCYCLIC GUANINE DERIVATIVES AND USE THEREOF | SCHERING CORPORATION | 2011-03-17 | — | — | US | disclosed |
| US-20110065738-A1 | POLYCYCLIC GUANINE DERIVATIVES AND USE THEREOF | SCHERING CORPORATION | 2011-03-17 | — | — | US | disclosed |
| US-20110065738-A1 | POLYCYCLIC GUANINE DERIVATIVES AND USE THEREOF | SCHERING CORPORATION | 2011-03-17 | — | — | US | disclosed |
| WO-2009002423-A2 | POLYCYCLIC GUANINE DERIVATIVES AND USE THEREOF | SCHERING CORPORATION (US) | 2008-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120316176-A1 | DERIVATIVES OF 7,8-DIHYDRO-1H-IMIDAZO[2,1-b] PURIN-4(5H)-ONE and METHODS OF USE THEREOF | P2RX7, P2RX4, P2RX3 | PNP 308/4885YTHDC1 1679/4885CDK1 3960/4885 |
| US-20110065738-A1 | POLYCYCLIC GUANINE DERIVATIVES AND USE THEREOF | GDA, HPRT1, GMPS | PNP 47/4885YTHDC1 1755/4885CDK1 1444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.