Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 9/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 5/20 | 0.45 |
| ▸ | TSHR | P16473 | 5/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.43 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1246085 | 0.83 | CYP2D6 (0.47) | CYP3A4ALDH1A1KMT2ACYP2D6CYP2C9 | |
| SCHEMBL2142414 | 0.80 | CYP3A4 (0.45) | CYP3A4ALDH1A1KMT2ACYP2D6CYP2C9 | |
| SCHEMBL17611709 | 0.78 | OPRM1 (0.48) | CYP3A4ALDH1A1KMT2ACYP2D6CYP2C9 | |
| SCHEMBL19341596 | 0.74 | CYP3A4 (0.49) | CYP3A4ALDH1A1KMT2ACYP2D6CYP2C9 | |
| SCHEMBL1121779 | 0.73 | CYP3A4 (0.51) | CYP3A4ALDH1A1KMT2ACYP2D6CYP2C9 | |
| SCHEMBL27545187 | 0.72 | KMT2A (0.74) | ALDH1A1KMT2AUSP2MAOBKDM4E | |
| SCHEMBL3329277 | 0.71 | SMN1; SMN2 (0.43) | CYP3A4ALDH1A1KMT2ACYP2D6CYP2C9 | |
| SCHEMBL3328458 | 0.71 | SMN1; SMN2 (0.43) | CYP3A4ALDH1A1KMT2ACYP2D6CYP2C9 | |
| SCHEMBL3332875 | 0.71 | SMN1; SMN2 (0.43) | CYP3A4ALDH1A1KMT2ACYP2D6CYP2C9 | |
| SCHEMBL17611770 | 0.70 | CHRM2 (0.69) | CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476265-B2 | Compounds-801 | ASTRAZENECA AB (SE) | 2013-07-02 | — | — | US | disclosed |
| US-8455483-B2 | Compounds—801 | ASTRAZENECA AB (SE) | 2013-06-04 | — | — | US | disclosed |
| US-20130018037-A1 | Compounds - 801 | ASTRAZENECA UK LIMITED (GB) | 2013-01-17 | — | — | US | disclosed |
| US-20110053909-A1 | Compounds - 801 | PULMAGEN THERAPEUTICS (SYNERGY) LIMITED (GB) | 2011-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130018037-A1 | Compounds - 801 | ADRA2C, ADRB2, ADRB1 | CYP3A4 532/4885ALDH1A1 264/4885KMT2A 2392/4885 |
| US-20110053909-A1 | Compounds - 801 | ADRA2C, ADRB2, ADRB1 | CYP3A4 532/4885ALDH1A1 264/4885KMT2A 2392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.