Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | EDNRB | P24530 | 2/20 | 0.45 |
| ▸ | EDNRA | P25101 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CTSG | P08311 | 3/20 | 0.40 |
| ▸ | KLK7 | P49862 | 3/20 | 0.40 |
| ▸ | KLK14 | Q9P0G3 | 3/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | CTRC | Q99895 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6026444 | 0.83 | BRD4 (0.43) | BRD4EDNRBEDNRAHPGDSALOX5AP | |
| SCHEMBL10849784 | 0.82 | BRD4 (0.42) | BRD4EDNRBEDNRAHPGDSLTA4H | |
| SCHEMBL1919495 | 0.78 | HPGDS (0.52) | BRD4EDNRBEDNRAHPGDSLTA4H | |
| SCHEMBL7408116 | 0.78 | BRD4 (0.41) | BRD4EDNRBEDNRAHPGDSALOX5AP | |
| SCHEMBL14600782 | 0.76 | ADRA1D (0.46) | RAB9ABRD4EDNRBEDNRAALOX5AP | |
| SCHEMBL5408419 | 0.76 | ALDH1A1 (0.48) | KDM4EALDH1A1BRD4EDNRBEDNRA | |
| SCHEMBL7402494 | 0.73 | EDNRB (0.41) | BRD4EDNRBEDNRAALOX5APFEN1 | |
| SCHEMBL3042288 | 0.73 | BRD4 (0.49) | ALDH1A1BRD4EDNRBEDNRAHPGDS | |
| SCHEMBL5352440 | 0.73 | EDNRA (0.50) | RAB9AKDM4EALDH1A1BRD4EDNRB | |
| SCHEMBL3031254 | 0.73 | RAB9A (0.53) | RAB9AKDM4EALDH1A1BRD4HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1435956-A2 | THERAPEUTIC COMBINATIONS FOR CARDIOVASCULAR AND INFLAMMATORY INDICATIONS | Pharmacia Corporation (US) | 2004-07-14 | — | — | EP | claimed |
| WO-2002078626-A2 | THERAPEUTIC COMBINATIONS FOR CARDIOVASCULAR AND INFLAMMATORY INDICATIONS | PHARMACIA CORPORATION (US) | 2002-10-10 | — | — | WO | claimed |
| EP-0699192-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-06 | — | — | EP | claimed |
| WO-1994027980-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | claimed |
| WO-2005009340-A2 | METHOD FOR THE TREATMENT OR PREVENTION OF RESPIRATORY DISORDERS WITH A CYCLOOXYGENASE-2 INHIBITOR IN COMBINATION WITH A MUSCARINIC RECEPTOR ANTAGONIST AND COMPOSITIONS THEREWITH | PHARMACIA CORPORATION (US) | 2005-02-03 | — | — | WO | disclosed |