Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SCN4A | P35499 | 1/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | AMPD2 | Q01433 | 9/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2335850 | 0.81 | AMPD2 (0.44) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL11660056 | 0.78 | ALDH1A1 (0.42) | LMNATSHRAMPD2HSD17B3NPC1 | |
| SCHEMBL859611 | 0.73 | LMNA (0.48) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL43169 | 0.73 | NOTUM (0.68) | LMNATSHRMAPK1NPC1MEN1 | |
| SCHEMBL29443491 | 0.73 | NOTUM (0.68) | LMNATSHRMAPK1NPC1MEN1 | |
| SCHEMBL3296716 | 0.72 | TSHR (0.71) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL18042443 | 0.72 | BRD4 (0.44) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL6173541 | 0.71 | NOTUM (0.51) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL3421961 | 0.71 | HSD17B3 (0.47) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL5026715 | 0.71 | NOTUM (0.51) | LMNATSHRMAPK1SCN4ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005018557-A2 | SUBSTITUTED PYRIDINONES | PHARMACIA CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |