Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SCN4A | P35499 | 1/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | P2RX4 | Q99571 | 7/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | AMPD2 | Q01433 | 6/20 | 0.38 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4858158 | 0.81 | TSHR (0.46) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL1286806 | 0.81 | LMNA (0.55) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL3838005 | 0.81 | NOTUM (0.49) | HSD17B3NOTUM | |
| Hydrochloric Acid SCHEMBL28145471 | 0.80 | LMNA (0.53) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL9183671 | 0.77 | P2RX4 (0.53) | LMNAMAPK1P2RX4BCHENPC1 | |
| SCHEMBL28223433 | 0.73 | LMNA (0.49) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL6526577 | 0.73 | LMNA (0.47) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL25961782 | 0.72 | LMNA (0.56) | LMNATSHRMAPK1SCN4ASCN5A | |
| SCHEMBL1068670 | 0.69 | LMNA (0.37) | LMNATSHRMAPK1SCN4ASCN5A | |
| Indole SCHEMBL28167409 | 0.69 | TRPA1 (0.44) | LMNATSHRMAPK1SCN4ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603883-B1 | QUINOLINE-DERIVED AMIDE MODULATORS OF VANILLOID VR1 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-28 | — | — | EP | disclosed |