Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 10/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.53 |
| ▸ | CDC7 | O00311 | 1/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | PAK4 | O96013 | 1/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.53 |
| ▸ | PRKCB | P05771 | 1/20 | 0.53 |
| ▸ | INSR | P06213 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.53 |
| ▸ | PRKACA | P17612 | 1/20 | 0.53 |
| ▸ | FLT4 | P35916 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | JAK3 | P52333 | 1/20 | 0.53 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.53 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.53 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL654828 | 0.87 | AURKA (0.49) | AURKAAURKBCDC7CHEK1JAK2 | |
| SCHEMBL653980 | 0.82 | ALDH1A1 (0.55) | AURKAMAPK1 | |
| SCHEMBL650318 | 0.82 | ALDH1A1 (0.55) | AURKAMAPK1 | |
| SCHEMBL3893620 | 0.79 | AURKA (0.63) | AURKAAURKBCDC7CHEK1JAK2 | |
| SCHEMBL651126 | 0.78 | NPC1 (0.41) | JAK2 | |
| SCHEMBL653285 | 0.74 | DYRK1A (0.41) | JAK2MAPK1 | |
| SCHEMBL655164 | 0.73 | AURKA (0.42) | AURKAMAPK1 | |
| SCHEMBL3882930 | 0.71 | AURKA (0.62) | AURKAAURKBCDC7CHEK1JAK2 | |
| SCHEMBL3880311 | 0.71 | AURKA (0.73) | AURKAAURKBCDC7CHEK1JAK2 | |
| SCHEMBL3882862 | 0.69 | AURKA (1.00) | AURKAAURKBCDC7CHEK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119641-B2 | 1H-furo[3,2-C]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-21 | — | — | US | disclosed |