Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 15/20 | 0.48 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL653980 | 1.00 | ALDH1A1 (0.55) | ALDH1A1KDM4EMAPK1BDKRB1LMNA | |
| SCHEMBL652872 | 0.85 | BDKRB1 (0.45) | ALDH1A1MAPK1BDKRB1LMNATHRB | |
| SCHEMBL653508 | 0.85 | BDKRB1 (0.45) | ALDH1A1MAPK1BDKRB1LMNATHRB | |
| SCHEMBL651126 | 0.85 | NPC1 (0.41) | ALDH1A1KDM4EBDKRB1LMNA | |
| SCHEMBL652682 | 0.82 | AURKA (0.53) | MAPK1AURKA | |
| SCHEMBL655164 | 0.81 | AURKA (0.42) | ALDH1A1KDM4EMAPK1BDKRB1AURKA | |
| SCHEMBL653285 | 0.78 | DYRK1A (0.41) | ALDH1A1MAPK1 | |
| SCHEMBL653335 | 0.77 | FADS1 (0.36) | ALDH1A1KDM4EMAPK1AURKA | |
| SCHEMBL2912045 | 0.74 | CYP1A2 (0.42) | ALDH1A1KDM4EMAPK1BDKRB1LMNA | |
| SCHEMBL4290720 | 0.73 | ALDH1A1 (1.00) | ALDH1A1KDM4ELMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119641-B2 | 1H-furo[3,2-C]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-21 | — | — | US | disclosed |