Sugi Predict

Sugi Predict / Compounds / SCHEMBL655164

SCHEMBL655164

SCHEMBL655164

CC(C)(NC(=O)c1cc2[nH]nc(NC(=O)c3ccccc3N)c2o1)c1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ AURKA O14965 1/20 0.42
▸ PTGS1 P23219 2/20 0.38
▸ MAPK1 P28482 5/20 0.38
▸ P2RX1 P51575 1/20 0.37
▸ TACR3 P29371 1/20 0.36
▸ NPC1 O15118 2/20 0.35
▸ RAB9A P51151 2/20 0.35
▸ ALDH1A1 P00352 1/20 0.35
▸ GAA P10253 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ KDM4E B2RXH2 1/20 0.35
▸ CASP3 P42574 1/20 0.35
▸ SENP8 Q96LD8 1/20 0.35
▸ HSD17B10 Q99714 1/20 0.35
▸ SENP7 Q9BQF6 1/20 0.35
▸ SENP6 Q9GZR1 1/20 0.35
▸ IMPDH2 P12268 2/20 0.35
▸ ABL1 P00519 1/20 0.34
▸ BCR P11274 1/20 0.34
▸ FADS1 O60427 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4083477 0.89 AURKA (0.42) AURKAMAPK1TACR3NPC1RAB9A
SCHEMBL653335 0.88 FADS1 (0.36) AURKAPTGS1MAPK1P2RX1NPC1
SCHEMBL652230 0.88 RXFP1 (0.42) AURKAMAPK1TACR3ALDH1A1BDKRB1
SCHEMBL4088217 0.87 AURKA (0.51) AURKAMAPK1IMPDH2ABL1BCR
SCHEMBL4093020 0.87 CDC7 (0.44) AURKANPC1RAB9ASMN1; SMN2
SCHEMBL653933 0.86 MEN1 (0.43) AURKAP2RX1NPC1RAB9AALDH1A1
SCHEMBL4078482 0.86 HPGD (0.46) AURKAMAPK1NPC1RAB9AALDH1A1
SCHEMBL653327 0.85 AURKA (0.40) AURKAMAPK1TACR3USP36
SCHEMBL4083487 0.85 SMN1; SMN2 (0.41) AURKAMAPK1NPC1RAB9AALDH1A1
SCHEMBL651126 0.85 NPC1 (0.41) PTGS1P2RX1NPC1RAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8119641-B2 1H-furo[3,2-C]pyrazole compounds useful as kinase inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2012-02-21 — — US disclosed
US-8119641-B2 1H-furo[3,2-C]pyrazole compounds useful as kinase inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2012-02-21 — — US disclosed
US-8119641-B2 1H-furo[3,2-C]pyrazole compounds useful as kinase inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2012-02-21 — — US disclosed
EP-2051981-B1 1H-FURO[3,2-C] PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES SRL (IT) 2010-08-25 — — EP disclosed
US-20090239924-A1 1H-FURO[3,2-C]PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2009-09-24 — — US disclosed
US-20090239924-A1 1H-FURO[3,2-C]PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2009-09-24 — — US disclosed
WO-2007138017-A1 1H-FURO[3,2-C] PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2007-12-06 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090239924-A1 1H-FURO[3,2-C]PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS IGF1R, CDK1, CDK15 AURKA 5/4885PTGS1 4479/4885MAPK1 185/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.