Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4170674 | 0.86 | PDK4 (0.59) | PDK4 | |
| SCHEMBL6711077 | 0.79 | ALDH1A1 (0.56) | LMNAHPGDUSP2ALDH1A1KDM4E | |
| SCHEMBL20140095 | 0.78 | HTR1A (0.54) | LMNAHPGDUSP2HTTALDH1A1 | |
| SCHEMBL22324761 | 0.76 | ALDH1A1 (0.47) | LMNAHPGDALDH1A1PDK4SMN1; SMN2 | |
| SCHEMBL6812374 | 0.76 | MAPT (0.44) | LMNAHPGDUSP2HTTALDH1A1 | |
| SCHEMBL25171673 | 0.76 | QDPR (0.47) | LMNAHPGDUSP2HTTALDH1A1 | |
| SCHEMBL19284621 | 0.76 | MAPT (0.47) | LMNAHPGDALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL15286283 | 0.74 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2CDK9ALOX15TSHR | |
| SCHEMBL6808255 | 0.74 | HTR1D (0.48) | HPGDALDH1A1KDM4EPDK4SMN1; SMN2 | |
| SCHEMBL20740133 | 0.72 | MAPT (0.47) | LMNAHTTKDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562917-A1 | BENZOXAZINONE DERIVATIVES, PREPARATION THEREOF AND USES IN THE TREATMENT OF CNS AND OTHER DISORDERS | GLAXO GROUP LIMITED (GB) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004046124-A1 | BENZOXAZINONE DERIVATIVES, PREPARATION THEREOF AND USES IN THE TREATMENT OF CNS AND OTHER DISORDERS | GLAXO GROUP LIMITED (GB) | 2004-06-03 | — | — | WO | disclosed |