Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 16/20 | 0.77 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.77 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.77 |
| ▸ | DRD4 | P21917 | 2/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.59 |
| ▸ | AKT1 | P31749 | 1/20 | 0.58 |
| ▸ | AKT2 | P31751 | 1/20 | 0.58 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.58 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | DRD1 | P21728 | 1/20 | 0.58 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.58 |
| ▸ | HTR7 | P34969 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.58 |
| ▸ | DRD3 | P35462 | 1/20 | 0.58 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.58 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.58 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3665096 | 0.87 | OPRM1 (1.00) | OPRM1OPRK1OPRL1DRD4CHRM1 | |
| SCHEMBL6496007 | 0.85 | OPRM1 (0.83) | OPRM1OPRK1OPRL1DRD4CHRM1 | |
| SCHEMBL8863557 | 0.83 | OPRM1 (0.91) | OPRM1OPRK1OPRL1DRD4CHRM1 | |
| Oxalic Acid SCHEMBL5778025 | 0.83 | OPRM1 (0.91) | OPRM1OPRK1OPRL1DRD4AKT1 | |
| SCHEMBL1577859 | 0.82 | OPRM1 (0.76) | OPRM1OPRK1OPRL1DRD4CHRM1 | |
| SCHEMBL6528066 | 0.82 | OPRM1 (0.76) | OPRM1OPRK1OPRL1DRD4CHRM1 | |
| SCHEMBL13959551 | 0.82 | OPRM1 (0.70) | OPRM1OPRK1OPRL1DRD4CHRM1 | |
| SCHEMBL8786338 | 0.82 | DRD4 (0.83) | DRD4DRD2DRD3 | |
| SCHEMBL20763210 | 0.81 | OPRM1 (1.00) | OPRM1OPRK1OPRL1DRD4CHRM1 | |
| SCHEMBL11223608 | 0.80 | OPRM1 (0.86) | OPRM1OPRK1OPRL1DRD4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050143372-A1 | Compounds, pharmaceutical compositions and methods of use therefor | MILLENNIUM PHARMACEUTICALS, INC. | 2005-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143372-A1 | Compounds, pharmaceutical compositions and methods of use therefor | CCR8, CCL11, CCR5 | OPRM1 494/4885OPRK1 246/4885OPRL1 140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.