Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.76 |
| ▸ | LMNA | P02545 | 2/20 | 0.76 |
| ▸ | POLB | P06746 | 2/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | RAB9A | P51151 | 2/20 | 0.66 |
| ▸ | GALR3 | O60755 | 1/20 | 0.66 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6085594 | 0.86 | HTT (0.71) | HTTLMNAPOLBNPSR1MAPT | |
| SCHEMBL17324721 | 0.85 | POLB (0.79) | HTTLMNAPOLBNPSR1MAPT | |
| SCHEMBL30049353 | 0.85 | POLB (0.79) | HTTLMNAPOLBNPSR1MAPT | |
| SCHEMBL4362980 | 0.84 | POLB (0.78) | HTTLMNAPOLBNPSR1MAPT | |
| SCHEMBL27933692 | 0.83 | POLB (1.00) | HTTPOLBNPSR1MAPTALDH1A1 | |
| SCHEMBL2916774 | 0.81 | HTT (0.55) | HTTLMNAPOLBNPSR1MAPT | |
| SCHEMBL17176648 | 0.78 | RAB9A (0.64) | HTTLMNAPOLBMAPTALDH1A1 | |
| SCHEMBL5171137 | 0.77 | HTR3A (0.53) | HTTLMNAALDH1A1RAB9AGALR3 | |
| SCHEMBL13564517 | 0.77 | NR4A2 (0.69) | HTTLMNAPOLBMAPTALDH1A1 | |
| SCHEMBL24273071 | 0.77 | LMNA (0.56) | HTTLMNAPOLBNPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110065715-A1 | Nogo Receptor Binding Small Molecules to Promote Axonal Growth | YALE UNIVERSITY (US) | 2011-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065715-A1 | Nogo Receptor Binding Small Molecules to Promote Axonal Growth | NGFR, GAP43, BDNF | HTT 337/4885LMNA 2215/4885POLB 3719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.