Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6531660 | 0.83 | ADORA2A (0.48) | ADORA1ADORA3ADORA2AADORA2BKMT2A | |
| SCHEMBL7749921 | 0.75 | ADORA1 (0.55) | ADORA1ADORA3ADORA2AADORA2BKMT2A | |
| SCHEMBL22587412 | 0.75 | ABCG2 (0.62) | ADORA1ADORA3ADORA2AADORA2BKMT2A | |
| SCHEMBL6530422 | 0.74 | ADORA1 (0.47) | ADORA1ADORA3ADORA2AADORA2BKMT2A | |
| SCHEMBL2231632 | 0.72 | ADORA1 (0.51) | ADORA1ADORA3ADORA2AADORA2BKMT2A | |
| SCHEMBL14274543 | 0.72 | ADORA1 (0.51) | ADORA1ADORA3ADORA2AADORA2BKMT2A | |
| SCHEMBL13655439 | 0.72 | KMT2A (0.63) | ADORA1ADORA3ADORA2AADORA2BKMT2A | |
| SCHEMBL3113348 | 0.68 | ABCG2 (0.63) | ADORA3KMT2AMEN1ALDH1A1TSHR | |
| SCHEMBL12426105 | 0.68 | TGFBR1 (0.66) | ADORA1ADORA3ADORA2AADORA2BKMT2A | |
| SCHEMBL22587420 | 0.67 | ACP1 (0.64) | ADORA1ADORA3ADORA2AADORA2BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050043332-A1 | Pyrrolo[2,3d]pyrimidine compositions and their use | OSI PHARMACEUTICALS, INC. | 2005-02-24 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043332-A1 | Pyrrolo[2,3d]pyrimidine compositions and their use | TYMP, UMPS, ADORA3 | ADORA1 38/4885ADORA3 3/4885ADORA2A 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.