Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 7/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 4/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 4/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 4/20 | 0.36 |
| ▸ | KIF11 | P52732 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5741790 | 0.84 | KIF11 (0.31) | PDK2KIF11 | |
| SCHEMBL6529219 | 0.82 | KIF11 (0.41) | PDK2KIF11 | |
| SCHEMBL5741839 | 0.80 | RXRA (0.37) | KIF11 | |
| SCHEMBL6506308 | 0.78 | KIF11 (0.44) | PDK2KIF11 | |
| SCHEMBL6507664 | 0.77 | KIF11 (0.40) | KIF11 | |
| SCHEMBL6510139 | 0.75 | KMT2A (0.41) | KIF11 | |
| SCHEMBL6504028 | 0.74 | MAPK14 (0.41) | — | |
| SCHEMBL5739316 | 0.74 | PDE4B (0.33) | — | |
| SCHEMBL5739318 | 0.74 | KIF11 (0.32) | KIF11 | |
| SCHEMBL5739313 | 0.74 | PDE4B (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050009820-A1 | Thiochromenones used to combat painful conditions and neurodegenerative diseases | BAYER HEALTHCARE AG (DE) | 2005-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009820-A1 | Thiochromenones used to combat painful conditions and neurodegenerative diseases | HTT, HMOX1, SNCA | PDK2 1295/4885PDK1 2013/4885PDK3 1093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.