Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 13/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 4/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6532445 | 0.93 | IKBKB (0.44) | CHEK1MAP4K4IKBKBJAK2JAK3 | |
| SCHEMBL6507152 | 0.78 | IKBKB (0.57) | CHEK1IKBKBJAK2JAK3HDAC6 | |
| SCHEMBL6505865 | 0.75 | IKBKB (0.58) | CHEK1MAP4K4IKBKBJAK2JAK3 | |
| SCHEMBL6507636 | 0.72 | IKBKB (0.51) | CHEK1IKBKBJAK2JAK3HDAC6 | |
| SCHEMBL6528389 | 0.71 | IKBKB (0.50) | CHEK1IKBKBHDAC6HDAC3HDAC4 | |
| SCHEMBL6505484 | 0.71 | CHEK1 (0.55) | CHEK1IKBKBJAK2JAK3HDAC6 | |
| SCHEMBL13667938 | 0.71 | CHEK1 (0.59) | CHEK1MAP4K4IKBKBJAK2JAK3 | |
| SCHEMBL491042 | 0.69 | IKBKB (0.55) | CHEK1IKBKBJAK2JAK3HDAC6 | |
| SCHEMBL6506758 | 0.69 | IKBKB (0.50) | CHEK1IKBKBJAK2JAK3MEN1 | |
| SCHEMBL6514837 | 0.68 | CHEK1 (0.47) | CHEK1IKBKBJAK2JAK3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |