Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.52 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.52 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.40 |
| ▸ | CLK2 | P49760 | 2/20 | 0.40 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.40 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.40 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | STK32B | Q9NY57 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.37 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17179205 | 0.76 | PIM1 (0.60) | PIM1PIM3PIM2LRRK2DYRK1A | |
| SCHEMBL6843856 | 0.75 | MAPKAPK2 (0.44) | LRRK2DYRK1ACLK2GRM4DCLK1 | |
| SCHEMBL27558691 | 0.72 | PIM1 (0.54) | PIM1PIM3PIM2LRRK2DYRK1A | |
| SCHEMBL2867324 | 0.71 | PIM1 (0.56) | PIM1PIM3PIM2LRRK2DYRK1A | |
| SCHEMBL5373231 | 0.70 | PIM1 (0.58) | PIM1PIM3PIM2LRRK2DYRK1A | |
| SCHEMBL5377743 | 0.70 | PIM1 (0.61) | PIM1PIM3PIM2LRRK2DYRK1A | |
| SCHEMBL2860104 | 0.68 | PIM1 (0.53) | PIM1PIM3PIM2LRRK2DYRK1A | |
| SCHEMBL10269245 | 0.66 | MAPKAPK2 (0.76) | PIM1PIM3PIM2LRRK2DYRK1A | |
| SCHEMBL3711976 | 0.65 | TTK (0.58) | PIM1PIM3PIM2LRRK2DYRK1A | |
| SCHEMBL32667946 | 0.63 | PDGFRB (0.77) | PDGFRBPDGFRACYP2A6NISCHTOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050009876-A1 | Indazole compounds, compositions thereof and methods of treatment therewith | SIGNAL PHARMACEUTICALS, LLC | 2005-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009876-A1 | Indazole compounds, compositions thereof and methods of treatment therewith | GPR119, JAK3, IGF1R | PIM1 172/4885PIM3 128/4885PIM2 251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.