Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.45 |
| ▸ | KDM5A | P29375 | 1/20 | 0.45 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | CYP2A13 | Q16696 | 2/20 | 0.39 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24844782 | 0.83 | PHF8 (0.53) | PHF8SMN1; SMN2RAB9AKDM2ALMNA | |
| SCHEMBL6529662 | 0.80 | PHF8 (0.54) | PHF8SMN1; SMN2RAB9AKDM2ALMNA | |
| SCHEMBL24844792 | 0.80 | PHF8 (0.51) | PHF8SMN1; SMN2RAB9AKDM2ALMNA | |
| SCHEMBL1196868 | 0.79 | HPGDS (0.51) | PHF8RAB9AKDM4CKDM5ACYP19A1 | |
| SCHEMBL10795248 | 0.79 | PHF8 (0.50) | PHF8SMN1; SMN2RAB9AKDM2ALMNA | |
| SCHEMBL6530474 | 0.76 | ALDH1A1 (0.43) | LMNAHTTKDM4CL3MBTL1MEN1 | |
| SCHEMBL9714098 | 0.74 | LMNA (0.50) | PHF8SMN1; SMN2RAB9AKDM2ALMNA | |
| SCHEMBL6531582 | 0.74 | CYP11B1 (0.49) | PHF8SMN1; SMN2RAB9AHTTKDM4C | |
| SCHEMBL19383009 | 0.71 | PHF8 (0.58) | PHF8KDM2AKDM4CKDM5AKDM2B | |
| SCHEMBL10567713 | 0.71 | MEN1 (0.60) | PHF8SMN1; SMN2RAB9ALMNAKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |