Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.70 |
| ▸ | HPGD | P15428 | 5/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | HPSE | Q9Y251 | 3/20 | 0.62 |
| ▸ | MMP2 | P08253 | 4/20 | 0.60 |
| ▸ | MMP13 | P45452 | 4/20 | 0.60 |
| ▸ | MMP9 | P14780 | 3/20 | 0.60 |
| ▸ | MMP8 | P22894 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
| ▸ | RELA | Q04206 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6527951 | 0.90 | HPSE (0.61) | KDM4EHPGDALDH1A1KMT2AHPSE | |
| SCHEMBL6529482 | 0.89 | HPSE (0.59) | KDM4EHPGDALDH1A1KMT2AHPSE | |
| SCHEMBL6514739 | 0.88 | MMP2 (0.80) | KDM4EHPGDALDH1A1KMT2AHPSE | |
| SCHEMBL16148287 | 0.88 | KDM4E (0.64) | KDM4EHPGDALDH1A1KMT2AMMP2 | |
| SCHEMBL16147869 | 0.88 | KDM4E (0.63) | KDM4EHPGDALDH1A1KMT2AHPSE | |
| SCHEMBL6506624 | 0.86 | HPSE (0.68) | KDM4EHPGDALDH1A1KMT2AHPSE | |
| SCHEMBL1664216 | 0.85 | KDM4E (0.97) | KDM4EHPGDALDH1A1KMT2AHPSE | |
| SCHEMBL6532368 | 0.84 | HDAC3 (0.64) | KDM4EALDH1A1KMT2AHPSEMMP2 | |
| SCHEMBL6506903 | 0.84 | HPSE (0.72) | KDM4EHPGDALDH1A1KMT2AHPSE | |
| SCHEMBL6511104 | 0.84 | HPSE (0.72) | KDM4EHPGDALDH1A1KMT2AHPSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005042496-A1 | (BENZIMIDAZOL-2-YL)-PHENYL-BENZYL-AMINE DERIVATIVES AND METHODS FOR INHIBITING HEPARANASE ACTIVITY | IMCLONE SYSTEMS INCORPORATED (US) | 2005-05-12 | — | — | WO | disclosed |