Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 3/20 | 0.68 |
| ▸ | MMP2 | P08253 | 2/20 | 0.64 |
| ▸ | MMP9 | P14780 | 2/20 | 0.64 |
| ▸ | MMP8 | P22894 | 2/20 | 0.64 |
| ▸ | MMP13 | P45452 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 8/20 | 0.62 |
| ▸ | RAB9A | P51151 | 8/20 | 0.62 |
| ▸ | PKM | P14618 | 4/20 | 0.62 |
| ▸ | KLF5 | Q13887 | 2/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | MAOB | P27338 | 1/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | SCD | O00767 | 1/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6514739 | 0.89 | MMP2 (0.80) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL6511104 | 0.88 | HPSE (0.72) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL6506903 | 0.88 | HPSE (0.72) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL6530461 | 0.86 | KDM4E (0.70) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL6527951 | 0.85 | HPSE (0.61) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL6529482 | 0.84 | HPSE (0.59) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL6532397 | 0.84 | NPC1 (0.65) | HPSENPC1RAB9AHDAC1SMN1; SMN2 | |
| SCHEMBL6281518 | 0.82 | HPSE (1.00) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL8820125 | 0.82 | HPSE (1.00) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL11703736 | 0.79 | NPC1 (0.91) | NPC1RAB9APKMKLF5SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005042496-A1 | (BENZIMIDAZOL-2-YL)-PHENYL-BENZYL-AMINE DERIVATIVES AND METHODS FOR INHIBITING HEPARANASE ACTIVITY | IMCLONE SYSTEMS INCORPORATED (US) | 2005-05-12 | — | — | WO | disclosed |