Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.40 |
| ▸ | NPC1 | O15118 | 6/20 | 0.40 |
| ▸ | RAB9A | P51151 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14161794 | 0.74 | MAPT (0.48) | ALDH1A1TSHRSMN1; SMN2NPC1RAB9A | |
| SCHEMBL12531879 | 0.73 | ADORA3 (0.46) | ALDH1A1TSHRSMN1; SMN2NPC1RAB9A | |
| SCHEMBL2228615 | 0.73 | SMN1; SMN2 (0.48) | ALDH1A1TSHRSMN1; SMN2NPC1RAB9A | |
| SCHEMBL8805105 | 0.72 | ALDH1A1 (0.52) | ALDH1A1L3MBTL1TSHRSMN1; SMN2NPC1 | |
| SCHEMBL8517029 | 0.71 | GAA (0.49) | ALDH1A1HPGDKDM4EGAAGLA | |
| SCHEMBL14161884 | 0.71 | MAPT (0.48) | ALDH1A1TSHRSMN1; SMN2NPC1RAB9A | |
| SCHEMBL13271298 | 0.70 | ADORA3 (0.46) | ALDH1A1SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL14161883 | 0.69 | MAPT (0.56) | ALDH1A1TSHRSMN1; SMN2NPC1RAB9A | |
| SCHEMBL30431911 | 0.68 | SMN1; SMN2 (0.47) | ALDH1A1TSHRSMN1; SMN2NPC1RAB9A | |
| SCHEMBL12442920 | 0.68 | KDM4E (0.50) | ALDH1A1L3MBTL1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0037265-B1 | 3-(1-PIPERIDINYLALKYL)-4H-PYRIDO(1,2-A)PYRIMIDIN-4-ONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-01-23 | — | — | EP | claimed |
| US-4342870-A | SEROTONIN ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1982-08-03 | — | — | US | claimed |
| EP-0037265-A1 | 3-(1-piperidinylalkyl)-4H-pyrido(1,2-a)pyrimidin-4-one derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-10-07 | — | — | EP | claimed |
| US-9834555-B2 | Method for treating pain syndrome and other disorders | VM Therapeutics LLC. (US) | 2017-12-05 | — | — | US | disclosed |
| US-20160318930-A1 | METHOD FOR TREATING PAIN SYNDROME AND OTHER DISORDERS | VM THERAPEUTICS LLC (US) | 2016-11-03 | — | — | US | disclosed |
| US-9402848-B2 | Method for treating pain syndrome and other disorders | VM THERAPEUTICS LLC (US) | 2016-08-02 | — | — | US | disclosed |
| US-20150150875-A1 | METHOD FOR TREATING PAIN SYNDROME AND OTHER DISORDERS | VM DISCOVERY, INC. | 2015-06-04 | — | — | US | disclosed |
| US-8980900-B2 | Method for treating pain syndrome and other disorders | VM Therapeutics, LLC. (US) | 2015-03-17 | — | — | US | disclosed |
| US-20140378476-A1 | METHOD FOR TREATING PAIN SYNDROME AND OTHER DISORDERS | VM DISCOVERY, INC. | 2014-12-25 | — | — | US | disclosed |
| US-8865727-B2 | Method for treating pain syndrome and other disorders | VM THERAPEUTICS LLC (US) | 2014-10-21 | — | — | US | disclosed |
| US-20110053960-A1 | METHOD FOR TREATING PAIN SYNDROME AND OTHER DISORDERS | VM DISCOVERY INC. (US) | 2011-03-03 | — | — | US | disclosed |
| EP-0037265-B1 | 3-(1-PIPERIDINYLALKYL)-4H-PYRIDO(1,2-A)PYRIMIDIN-4-ONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-01-23 | — | — | EP | disclosed |
| US-4342870-A | SEROTONIN ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1982-08-03 | — | — | US | disclosed |
| EP-0037265-A1 | 3-(1-piperidinylalkyl)-4H-pyrido(1,2-a)pyrimidin-4-one derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-10-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140378476-A1 | METHOD FOR TREATING PAIN SYNDROME AND OTHER DISORDERS | CACNA1G, CACNA1H, CACNA1A | ALDH1A1 3240/4885L3MBTL1 2952/4885TSHR 2173/4885 |
| US-20150150875-A1 | METHOD FOR TREATING PAIN SYNDROME AND OTHER DISORDERS | CACNA1G, CACNA1H, CACNA1A | ALDH1A1 3240/4885L3MBTL1 2952/4885TSHR 2173/4885 |
| US-20160318930-A1 | METHOD FOR TREATING PAIN SYNDROME AND OTHER DISORDERS | CACNA1G, CACNA1H, CACNA1A | ALDH1A1 3240/4885L3MBTL1 2952/4885TSHR 2173/4885 |
| US-20110053960-A1 | METHOD FOR TREATING PAIN SYNDROME AND OTHER DISORDERS | CACNA1G, CACNA1H, CACNA1A | ALDH1A1 3240/4885L3MBTL1 2952/4885TSHR 2173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.