Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 8/20 | 0.39 |
| ▸ | DRD3 | P35462 | 8/20 | 0.39 |
| ▸ | HTR6 | P50406 | 8/20 | 0.39 |
| ▸ | HTR2C | P28335 | 7/20 | 0.39 |
| ▸ | HTR2A | P28223 | 6/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12677449 | 0.83 | DRD2 (0.47) | CYP2D6DRD2DRD3HTR6HTR2C | |
| SCHEMBL30471166 | 0.79 | GRM5 (0.51) | — | |
| SCHEMBL25252571 | 0.79 | GRM5 (0.51) | — | |
| SCHEMBL8318207 | 0.78 | CASP1 (0.52) | CYP1A2MAOAMAOB | |
| SCHEMBL30471246 | 0.76 | GRM5 (0.39) | DRD2DRD3HTR6HTR2CHTR2A | |
| SCHEMBL25213922 | 0.76 | GRM5 (0.39) | DRD2DRD3HTR6HTR2CHTR2A | |
| SCHEMBL26608676 | 0.72 | MAOA (0.62) | DRD2DRD3HTR2CHTR2AMAOA | |
| SCHEMBL25690759 | 0.72 | HTR6 (0.44) | DRD2DRD3HTR6HTR2CHTR2A | |
| SCHEMBL38660212 | 0.71 | POLB (0.43) | CYP2D6DRD3HTR6CYP3A4CYP1A2 | |
| SCHEMBL3200431 | 0.71 | POLB (0.43) | CYP2D6DRD3HTR6CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016891-A1 | 7-PHENYLSULFONYL-TETRAHYDRO-3-BENZAZEPINE DERIVATIVES AS ANTIPSYCHOTIC AGENTS | GLAXO GROUP LIMITED (GB) | 2005-02-24 | — | — | WO | disclosed |