SCHEMBL653292

SCHEMBL653292

NC(=S)Nc1cccc(Cl)c1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 4/20 0.68
ALDH1A1 P00352 4/20 0.68
MAPT P10636 2/20 0.68
IDO1 P14902 1/20 0.68
KMT2A Q03164 3/20 0.63
CYP1A2 P05177 1/20 0.61
HTR3E A5X5Y0 2/20 0.61
HTR3B O95264 2/20 0.61
HTR3A P46098 2/20 0.61
HTR3D Q70Z44 2/20 0.61
HTR3C Q8WXA8 2/20 0.61
MEN1 O00255 2/20 0.60
LMNA P02545 1/20 0.60
HTT P42858 1/20 0.60
NPC1 O15118 1/20 0.58
RAB9A P51151 1/20 0.58
MAOA P21397 1/20 0.57
MAOB P27338 1/20 0.57
TP53 P04637 1/20 0.57
TYR P14679 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11449848 0.89 IDO1 (0.70) GAAALDH1A1MAPTIDO1KMT2A
SCHEMBL4047674 0.85 KMT2A (0.76) GAAALDH1A1MAPTIDO1KMT2A
SCHEMBL10481432 0.84 IDO1 (0.62) GAAALDH1A1MAPTIDO1KMT2A
SCHEMBL22274845 0.84 IDO1 (0.73) GAAALDH1A1MAPTIDO1KMT2A
SCHEMBL26991 0.83 IDO1 (0.79) GAAALDH1A1MAPTIDO1KMT2A
SCHEMBL29481122 0.83 IDO1 (0.79) GAAALDH1A1MAPTIDO1KMT2A
SCHEMBL11449846 0.83 IDO1 (0.66) GAAALDH1A1MAPTIDO1KMT2A
SCHEMBL11260245 0.82 IDO1 (0.65) GAAALDH1A1MAPTIDO1KMT2A
SCHEMBL9690067 0.81 GAA (1.00) GAAALDH1A1MAPTIDO1KMT2A
SCHEMBL5437433 0.81 IDO1 (1.00) GAAALDH1A1MAPTIDO1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 149 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114432901-B Composite membrane with acid resistance and alkali resistance as well as preparation method and application thereof 中国石油化工股份有限公司 2023-04-11 CN claimed
CN-114432901-A Composite membrane with acid resistance and alkali resistance as well as preparation method and application thereof 中国石油化工股份有限公司 2022-05-06 CN claimed
JP-55000344-A None JP disclosed
US-20250092020-A1 IDO/TDO Inhibitor GENERAL INCORPORATED ASSOCIATION PHARMA VALLEY PROJECT SUPPORTING ORGANIZATION (JP) 2025-03-20 US disclosed
US-12209079-B2 IDO/TDO inhibitor GENERAL INCORPORATED ASSOCIATION PHARMA VALLEY PROJECT SUPPORTING ORGANIZATION (JP) 2025-01-28 US disclosed
US-20250011315-A1 ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS AND USES THEREOF PRISM MEDICINES, INC. 2025-01-09 US disclosed
US-12030876-B2 Aryl hydrocarbon receptor (AHR) agonists and uses thereof Ikena Oncology, Inc. (US) 2024-07-09 US disclosed
US-12030876-B2 Aryl hydrocarbon receptor (AHR) agonists and uses thereof Ikena Oncology, Inc. (US) 2024-07-09 US disclosed
US-12030876-B2 Aryl hydrocarbon receptor (AHR) agonists and uses thereof Ikena Oncology, Inc. (US) 2024-07-09 US disclosed
US-20240165983-A1 DRAWING SYSTEM AND DRAWING METHOD Sony Group Corporation (JP) 2024-05-23 US disclosed
US-20230295147-A1 ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS AND USES THEREOF ARYL THERAPEUTICS, INC. 2023-09-21 US disclosed
CN-1035253-C Pyranyl cyanoguanidine derivatives SQUIBB & SONS INC (US) 1997-06-25 CN disclosed
EP-0666507-A2 Negative charging type printing photosensitive resin composition Nippon Paint Co., Ltd. (JP) 1995-08-09 EP disclosed
CN-1064272-A PYRANYL CYANOGUANIDINE DERIVATIVES SQUIBB & SONS INC (US) 1992-09-09 CN disclosed
US-4713382-A N-phenyl-4-phenyl-1-piperazinecarboxamidines and related compounds as antiarrhythmic agents SYNTEX (U.S.A.) INC. (US) 1987-12-15 US disclosed
CN-86103798-A The preparation method of N-phenyl-4-phenyl-1-piperazine carbonamidine and their purposes as anti-arrhythmic 1987-06-10 CN disclosed
EP-0204265-A1 N-Phenyl-4-phenyl-1-piperazine carboxamidines and related compounds as antiarrhythmic agents LABORATOIRES SYNTEX S.A. (FR) 1986-12-10 EP disclosed
US-4252963-A CYCLIZATION OF PHENYLTHIOUREAS WITH THIONYL CHLORIDE HOECHST AKTIENGESELLSCHAFT (DE) 1981-02-24 US disclosed
US-4225591-A CORONARY VASODILATOR TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1980-09-30 US disclosed
JP-S55344-A 2-NITROSOIMINOBENZTHIAZOLINE DERIVATIVE IWAKI SEIYAKU KK 1980-01-05 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12209079-B2 IDO/TDO inhibitor IDO1, IDO2, TDO2 GAA 3551/4885ALDH1A1 3331/4885MAPT 609/4885
US-20250011315-A1 ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS AND USES THEREOF AHR, ARNT, HCAR1 GAA 3146/4885ALDH1A1 289/4885MAPT 4673/4885
US-12030876-B2 Aryl hydrocarbon receptor (AHR) agonists and uses thereof AHR, ARNT, HCAR1 GAA 3146/4885ALDH1A1 289/4885MAPT 4673/4885
US-20230295147-A1 ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS AND USES THEREOF AHR, ARNT, HCAR1 GAA 3146/4885ALDH1A1 289/4885MAPT 4673/4885
US-20250092020-A1 IDO/TDO Inhibitor IDO1, IDO2, TDO2 GAA 3551/4885ALDH1A1 3331/4885MAPT 609/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.