Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 5/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL652230 | 0.88 | RXFP1 (0.42) | AURKAFGFR4LMNAPPARGNR1H4 | |
| SCHEMBL2909804 | 0.88 | FGFR4 (0.40) | FGFR4KITALDH1A1HPGDL3MBTL1 | |
| SCHEMBL2914426 | 0.87 | KIT (0.35) | AURKAFGFR4RETLMNAPPARG | |
| SCHEMBL651483 | 0.87 | EGLN1 (0.40) | AURKAFGFR4LMNAPPARGNR1H4 | |
| SCHEMBL650566 | 0.86 | AURKA (0.40) | AURKAFGFR4LMNAPPARGNR1H4 | |
| SCHEMBL653327 | 0.85 | AURKA (0.40) | AURKAFGFR4LMNAL3MBTL1MAPK1 | |
| SCHEMBL651124 | 0.85 | AURKA (0.40) | AURKAFGFR4LMNAPPARGNR1H4 | |
| SCHEMBL651489 | 0.85 | RXFP1 (0.47) | AURKAFGFR4ALDH1A1RAB9AMEN1 | |
| SCHEMBL652354 | 0.83 | AURKA (0.41) | AURKAFGFR4LMNAKITALDH1A1 | |
| SCHEMBL654837 | 0.83 | AURKA (0.42) | AURKAFGFR4LMNAPPARGNR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119641-B2 | 1H-furo[3,2-C]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-21 | — | — | US | claimed |
| US-8119641-B2 | 1H-furo[3,2-C]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-21 | — | — | US | disclosed |