Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | ALPI | P09923 | 1/20 | 0.37 |
| ▸ | ALPG | P10696 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | USP36 | Q9P275 | 1/20 | 0.34 |
| ▸ | TACR3 | P29371 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL652230 | 0.90 | RXFP1 (0.42) | AURKAMAPK1CYP2C19FGFR4LMNA | |
| SCHEMBL2912045 | 0.87 | CYP1A2 (0.42) | MAPK1CYP1A2CYP2C9ALPLALPI | |
| SCHEMBL651489 | 0.85 | RXFP1 (0.47) | AURKAMAPK1FGFR4RXFP1 | |
| SCHEMBL653328 | 0.85 | AURKA (0.38) | AURKAMAPK1FGFR4LMNARXFP1 | |
| SCHEMBL651124 | 0.85 | AURKA (0.40) | AURKAFGFR4LMNARXFP1L3MBTL1 | |
| SCHEMBL655164 | 0.85 | AURKA (0.42) | AURKAMAPK1USP36TACR3 | |
| SCHEMBL4083477 | 0.85 | AURKA (0.42) | AURKAMAPK1LMNATACR3 | |
| SCHEMBL652354 | 0.84 | AURKA (0.41) | AURKAFGFR4LMNARXFP1 | |
| SCHEMBL651483 | 0.84 | EGLN1 (0.40) | AURKAMAPK1FGFR4LMNARXFP1 | |
| SCHEMBL654837 | 0.84 | AURKA (0.42) | AURKAFGFR4LMNARXFP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119641-B2 | 1H-furo[3,2-C]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-21 | — | — | US | disclosed |