Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | TACR3 | P29371 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL653327 | 0.90 | AURKA (0.40) | RXFP1AURKAFGFR4LMNAL3MBTL1 | |
| SCHEMBL653354 | 0.88 | RXFP1 (0.38) | RXFP1FGFR4LMNAALDH1A1KIT | |
| SCHEMBL651489 | 0.88 | RXFP1 (0.47) | RXFP1AURKAFGFR4ALDH1A1POLB | |
| SCHEMBL651124 | 0.88 | AURKA (0.40) | RXFP1AURKAFGFR4LMNAALDH1A1 | |
| SCHEMBL653328 | 0.88 | AURKA (0.38) | RXFP1AURKAFGFR4LMNAALDH1A1 | |
| SCHEMBL4083477 | 0.88 | AURKA (0.42) | AURKALMNAALDH1A1HPGDMAPK1 | |
| SCHEMBL655164 | 0.88 | AURKA (0.42) | AURKAALDH1A1BDKRB1MAPK1TACR3 | |
| SCHEMBL651483 | 0.86 | EGLN1 (0.40) | RXFP1AURKAFGFR4LMNAMAPK1 | |
| SCHEMBL654837 | 0.86 | AURKA (0.42) | RXFP1AURKAFGFR4LMNAALDH1A1 | |
| SCHEMBL652354 | 0.86 | AURKA (0.41) | RXFP1AURKAFGFR4LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119641-B2 | 1H-furo[3,2-C]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-21 | — | — | US | disclosed |