Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | BCR | P11274 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | RXFP2 | Q8WXD0 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4078547 | 0.94 | AURKA (0.46) | AURKARAB9AHPGDSMN1; SMN2EGLN1 | |
| SCHEMBL652354 | 0.89 | AURKA (0.41) | AURKAKITRAB9AFGFR4SMN1; SMN2 | |
| SCHEMBL2907895 | 0.88 | RAB9A (0.39) | KITRAB9AFGFR4HPGDSMN1; SMN2 | |
| SCHEMBL652262 | 0.88 | AURKA (0.54) | AURKAKITABL1BCR | |
| SCHEMBL2913928 | 0.87 | AURKA (0.37) | AURKAKITRAB9AFGFR4HPGD | |
| SCHEMBL651138 | 0.87 | AURKA (0.40) | AURKAKITFGFR4EGLN1LMNA | |
| SCHEMBL650566 | 0.86 | AURKA (0.40) | AURKAKITRAB9AFGFR4HPGD | |
| SCHEMBL652230 | 0.86 | RXFP1 (0.42) | AURKAKITFGFR4HPGDPPARG | |
| SCHEMBL4314119 | 0.84 | EGLN1 (0.34) | AURKARAB9AHPGDSMN1; SMN2EGLN1 | |
| SCHEMBL653327 | 0.84 | AURKA (0.40) | AURKAFGFR4LMNARXFP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119641-B2 | 1H-furo[3,2-C]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-21 | — | — | US | claimed |
| US-8119641-B2 | 1H-furo[3,2-C]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-21 | — | — | US | disclosed |