Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FADS1 | O60427 | 3/20 | 0.36 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL653354 | 0.88 | RXFP1 (0.38) | SMN1; SMN2ALDH1A1GLANPC1RAB9A | |
| SCHEMBL655164 | 0.88 | AURKA (0.42) | FADS1P2RX1SMN1; SMN2PTGS1ALDH1A1 | |
| SCHEMBL4084047 | 0.87 | AURKA (0.42) | AURKAHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL652599 | 0.87 | MEN1 (0.41) | P2RX1SMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL4082088 | 0.85 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1NPC1RAB9AMAPK1 | |
| SCHEMBL653322 | 0.85 | ALK (0.54) | AURKAINSRIGF1RALKKDR | |
| SCHEMBL4091695 | 0.84 | MAPK1 (0.45) | SMN1; SMN2ALDH1A1NPC1RAB9AGAA | |
| SCHEMBL4083477 | 0.84 | AURKA (0.42) | SMN1; SMN2ALDH1A1GLAAURKANPC1 | |
| SCHEMBL13850096 | 0.84 | AURKA (0.39) | AURKAINSRIGF1RALKHDAC6 | |
| SCHEMBL652592 | 0.84 | PPARG (0.35) | SMN1; SMN2ALDH1A1GLAAURKANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119641-B2 | 1H-furo[3,2-C]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-21 | — | — | US | disclosed |