Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 8/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL653335 | 0.88 | FADS1 (0.36) | ALDH1A1KDM4ESMN1; SMN2GLANPC1 | |
| SCHEMBL652592 | 0.88 | PPARG (0.35) | FGFR4LMNAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL652230 | 0.88 | RXFP1 (0.42) | RXFP1FGFR4KITBRAFLMNA | |
| SCHEMBL4084047 | 0.86 | AURKA (0.42) | — | |
| SCHEMBL652599 | 0.86 | MEN1 (0.41) | ALDH1A1KDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL4082088 | 0.84 | SMN1; SMN2 (0.41) | RXFP1LMNAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL4091695 | 0.84 | MAPK1 (0.45) | ALDH1A1KDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL4083477 | 0.83 | AURKA (0.42) | LMNAALDH1A1KDM4ESMN1; SMN2GLA | |
| SCHEMBL2904998 | 0.82 | GPR35 (0.47) | RXFP1FGFR4KITBRAFALDH1A1 | |
| SCHEMBL13850096 | 0.81 | AURKA (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119641-B2 | 1H-furo[3,2-C]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-21 | — | — | US | disclosed |