Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 7/20 | 0.39 |
| ▸ | NPC1 | O15118 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4084047 | 0.88 | AURKA (0.42) | — | |
| SCHEMBL4082088 | 0.86 | SMN1; SMN2 (0.41) | MAPK1SMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL653335 | 0.84 | FADS1 (0.36) | MAPK1SMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL653354 | 0.84 | RXFP1 (0.38) | SMN1; SMN2RAB9ANPC1ALDH1A1KDM4E | |
| SCHEMBL13850096 | 0.83 | AURKA (0.39) | — | |
| SCHEMBL652599 | 0.82 | MEN1 (0.41) | SMN1; SMN2RAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL652592 | 0.80 | PPARG (0.35) | SMN1; SMN2RAB9ANPC1ALDH1A1KMT2A | |
| SCHEMBL4083477 | 0.79 | AURKA (0.42) | MAPK1SMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL4088412 | 0.79 | ABL1 (0.51) | RAB9AALDH1A1KDM4EMAPT | |
| SCHEMBL4082899 | 0.79 | AURKA (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |