Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trinitrophenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | GPR35 | Q9HC97 | 5/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | TTR | P02766 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trinitrophenol SCHEMBL1503374 | 0.95 | ALDH1A1 (0.55) | ALDH1A1GPR35TDP1HPGDMAPK1 | |
| Trinitrophenol SCHEMBL7161635 | 0.95 | ALDH1A1 (0.55) | ALDH1A1GPR35TDP1HPGDMAPK1 | |
| Trinitrophenol SCHEMBL1132384 | 0.95 | ALDH1A1 (0.55) | ALDH1A1GPR35TDP1HPGDMAPK1 | |
| Trinitrophenol SCHEMBL597737 | 0.95 | ALDH1A1 (0.55) | ALDH1A1GPR35TDP1HPGDMAPK1 | |
| Trinitrophenol SCHEMBL2218621 | 0.95 | ALDH1A1 (0.55) | ALDH1A1GPR35TDP1HPGDMAPK1 | |
| Trinitrophenol SCHEMBL11746242 | 0.95 | ALDH1A1 (0.55) | ALDH1A1GPR35TDP1HPGDMAPK1 | |
| Trinitrophenol SCHEMBL11029128 | 0.95 | ALDH1A1 (0.55) | ALDH1A1GPR35TDP1HPGDMAPK1 | |
| Trinitrophenol SCHEMBL2197455 | 0.95 | ALDH1A1 (0.55) | ALDH1A1GPR35TDP1HPGDMAPK1 | |
| Trinitrophenol SCHEMBL48278 | 0.95 | ALDH1A1 (0.55) | ALDH1A1GPR35TDP1HPGDMAPK1 | |
| Trinitrophenol SCHEMBL5908862 | 0.95 | ALDH1A1 (0.55) | ALDH1A1GPR35TDP1HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 97 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2182947-B1 | COMPOSITIONS WITH ENHANCED BIOAVAILABILITY AND FAST ACTING INHIBITOR OF GASTRIC ACID SECRETION | UNIV YALE (US) | 2019-09-04 | — | — | EP | claimed |
| CN-105252622-A | Method for manufacturing craft through waste bamboo | ANHUI LIAOYUAN TRADE CO LTD | 2016-01-20 | — | — | CN | claimed |
| WO-2015153552-A1 | FAST ACTING INHIBITOR OF GASTRIC ACID SECRETION WITH ENHANCED ACTIVITY | YALE UNIVERSITY (US) | 2015-10-08 | — | — | WO | claimed |
| US-20150231175-A1 | COMPOSITIONS WITH ENHANCED BIOAVAILABILITY AND FAST ACTING INHIBITOR OF GASTRIC ACID SECRETION | UNIV YALE (US) | 2015-08-20 | — | — | US | claimed |
| US-20140154339-A1 | Fast Acting Inhibitor of Gastric Acid Secretion | YALE UNIVERSITY | 2014-06-05 | — | — | US | claimed |
| CN-102014939-A | Homeopathic formulations | DEVICHAND OSWAL GUNVANT | 2011-04-13 | — | — | CN | claimed |
| US-20100150861-A1 | COMPOSTIONS WITH ENHANCED BIOAVAILABILITY AND FAST ACTING INHIBITOR OR GASTRIC ACID SECRETION | YALE UNIVERSITY (US) | 2010-06-17 | — | — | US | claimed |
| EP-2182947-A2 | COMPOSITIONS WITH ENHANCED BIOAVAILABILITY AND FAST ACTING INHIBITOR OF GASTRIC ACID SECRETION | YALE UNIVERSITY (US) | 2010-05-12 | — | — | EP | claimed |
| WO-2009017624-A2 | COMPOSITIONS WITH ENHANCED BIOAVAILABILITY AND FAST ACTING INHIBITOR OF GASTRIC ACID SECRETION | YALE UNIVERSITY (US) | 2009-02-05 | — | — | WO | claimed |
| US-20080038368-A1 | Fast acting inhibitor of gastric acid secretion | YALE UNIVERSITY (US) | 2008-02-14 | — | — | US | claimed |
| EP-0589047-B1 | METHOD OF TREATING INFECTIOUS DISEASE, METHOD OF PREVENTING PUTREFACTION OF COSMETIC, AND ANTIBACTERIAL/ANTIFUNGAL AGENT AND COSMETIC | OTSUKA PHARMA CO LTD (JP) | 1999-06-09 | — | — | EP | claimed |
| CN-1144599-A | Treatment method and liquid for withered green plant recovering its active state | ZHANG CHENGZHI (CN) | 1997-03-12 | — | — | CN | claimed |
| EP-0589047-A1 | METHOD OF TREATING INFECTIOUS DISEASE, METHOD OF PREVENTING PUTREFACTION OF COSMETIC, AND ANTIBACTERIAL/ANTIFUNGAL AGENT AND COSMETIC | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-03-30 | — | — | EP | claimed |
| US-4455150-A | Chemically enhanced combustion of water-slurry fuels | OLEN KENNETH R | 1984-06-19 | — | — | US | claimed |
| US-12570541-B1 | Multiphase nanocomposite material production | IMAM MOHAMMAD IBN SAUD ISLAMIC UNIVERSITY (SA) | 2026-03-10 | — | — | US | disclosed |
| US-12508569-B1 | Multiphase nanocomposite material | IMAM MOHAMMAD IBN SAUD ISLAMIC UNIVERSITY (SA) | 2025-12-30 | — | — | US | disclosed |
| US-12421125-B1 | Particulate nanocomposite material | IMAM MOHAMMAD IBN SAUD ISLAMIC UNIVERSITY (SA) | 2025-09-23 | — | — | US | disclosed |
| US-4455150-A | Chemically enhanced combustion of water-slurry fuels | OLEN KENNETH R | 1984-06-19 | — | — | US | disclosed |
| US-4125474-A | Process for producing ferrogmagnetic iron oxide powder comprising a pre-treatment with a reducing agent | FUJI PHOTO FILM CO., LTD. (JP) | 1978-11-14 | — | — | US | disclosed |
| US-4069164-A | COBALT-CONTAINING IRON OXIDE, OXIDIZER | FUJI PHOTO FILM CO., LTD. (JA) | 1978-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12570541-B1 | Multiphase nanocomposite material production | ZKSCAN2, ZRANB2, FTH1 | ALDH1A1 4038/4885GPR35 4466/4885TDP1 4872/4885 |
| US-12508569-B1 | Multiphase nanocomposite material | ZKSCAN2, OCIAD2, ZRANB2 | ALDH1A1 4810/4885GPR35 4792/4885TDP1 3797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.