Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.34 |
| ▸ | PPARD | Q03181 | 5/20 | 0.33 |
| ▸ | PPARA | Q07869 | 5/20 | 0.33 |
| ▸ | ACACB | O00763 | 7/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6325563 | 0.79 | MITF (0.51) | FFAR1TSHR | |
| SCHEMBL6533171 | 0.68 | HCAR2 (0.33) | FFAR1S1PR1HCAR2DPP4DPP7 | |
| SCHEMBL6472559 | 0.66 | ACACB (0.60) | FFAR1PPARDPPARAACACBS1PR1 | |
| SCHEMBL10312539 | 0.63 | HCAR2 (0.51) | S1PR1HCAR2TSHR | |
| SCHEMBL6333227 | 0.63 | ALDH1A1 (0.54) | FFAR1TSHR | |
| SCHEMBL563100 | 0.63 | PPARD (0.54) | FFAR1PPARDPPARAACACBHCAR2 | |
| SCHEMBL22842957 | 0.59 | L3MBTL1 (0.54) | EPHX2TSHRNR1H2NR1H3 | |
| SCHEMBL4548425 | 0.59 | HCAR2 (0.49) | FFAR1PPARDPPARAHCAR2 | |
| SCHEMBL6334787 | 0.59 | ZAP70 (0.32) | FFAR1HCAR2 | |
| SCHEMBL4250812 | 0.59 | HCAR3 (0.49) | EPHX2HCAR3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423120-A4 | 2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF | ICOS CORP (US) | 2005-12-28 | — | — | EP | disclosed |
| EP-1423120-A1 | 2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF | ICOS CORPORATION (US) | 2004-06-02 | — | — | EP | disclosed |
| WO-2003015785-A1 | 2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF | ICOS CORPORATION (US) | 2003-02-27 | — | — | WO | disclosed |