Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.42 |
| ▸ | MGMT | P16455 | 1/20 | 0.42 |
| ▸ | POLA1 | P09884 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL325149 | 0.81 | PDPK1 (0.54) | DPP4CDK2CDK1CCNB1CCNA2 | |
| SCHEMBL29559859 | 0.81 | PDPK1 (0.54) | DPP4CDK2CDK1CCNB1CCNA2 | |
| SCHEMBL5576430 | 0.81 | CDK2 (0.42) | DPP4CDK2CDK1CCNB1CCNA2 | |
| SCHEMBL7293081 | 0.78 | DPP4 (0.56) | DPP4CDK2CDK1CCNB1CCNA2 | |
| SCHEMBL490903 | 0.77 | CDK2 (0.47) | CDK2CDK1CCNB1CCNA2CCNA1 | |
| SCHEMBL6533714 | 0.74 | — | — | |
| SCHEMBL29853238 | 0.74 | DPP4 (0.51) | DPP4CDK2CDK1CCNB1CCNA2 | |
| SCHEMBL8588220 | 0.74 | DPP4 (0.47) | DPP4CDK2CDK1CCNB1CCNA2 | |
| SCHEMBL10428052 | 0.72 | DPP4 (0.57) | DPP4CDK2CDK1CCNB1CCNA2 | |
| SCHEMBL7359078 | 0.72 | HRH4 (0.43) | PDPK1ADORA3MAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050227933-A1 | Treatment of bacterial induced diseases using DNA methyl transferase inhibitors | BENKOVIC STEPHEN J | 2005-10-13 | — | — | US | disclosed |
| US-20040259833-A1 | DNA methyl transferase inhibitors | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2004-12-23 | — | — | US | disclosed |
| EP-1420021-A1 | DNA Methyltransferase inhibitors | The Penn State Research Foundation (US) | 2004-05-19 | — | — | EP | disclosed |
| CN-1370170-A | DNA methyltransferase inhibitors | PENN STATE RES FOUND (US) | 2002-09-18 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050227933-A1 | Treatment of bacterial induced diseases using DNA methyl transferase inhibitors | DNMT1, TPMT, GNMT | DPP4 2447/4885CDK2 3167/4885CDK1 3219/4885 |
| US-20040259833-A1 | DNA methyl transferase inhibitors | DNMT1, DNMT3A, DIMT1 | DPP4 1033/4885CDK2 1385/4885CDK1 1591/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.