Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 19/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 4/20 | 0.52 |
| ▸ | HTR7 | P34969 | 3/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | HTR1D | P28221 | 1/20 | 0.52 |
| ▸ | HTR1B | P28222 | 1/20 | 0.52 |
| ▸ | HTR1E | P28566 | 1/20 | 0.52 |
| ▸ | HTR1F | P30939 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 5/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6529121 | 0.88 | CYP3A4 (0.74) | HTR6CYP3A4CYP2D6DRD2HTR7 | |
| SCHEMBL6530751 | 0.81 | CYP3A4 (0.64) | HTR6CYP3A4CYP2D6DRD2HTR7 | |
| SCHEMBL6528108 | 0.78 | HTR6 (0.60) | HTR6CYP3A4CYP2D6DRD2HTR7 | |
| SCHEMBL6529028 | 0.78 | HTR6 (0.60) | HTR6CYP3A4CYP2D6DRD2HTR1A | |
| SCHEMBL19737472 | 0.77 | HTR6 (0.66) | HTR6DRD2HTR7HTR1AHTR1D | |
| SCHEMBL6527747 | 0.77 | HTR6 (0.62) | HTR6CYP3A4CYP2D6HTR1AHTR2A | |
| SCHEMBL6532617 | 0.76 | CYP3A4 (0.79) | HTR6CYP3A4CYP2D6 | |
| SCHEMBL6529764 | 0.74 | HTR6 (0.61) | HTR6CYP3A4CYP2D6DRD2HTR7 | |
| SCHEMBL948631 | 0.74 | HTR6 (0.75) | HTR6DRD2HTR7HTR1AHTR1D | |
| Dimethylamine SCHEMBL21222407 | 0.74 | HTR6 (0.65) | HTR6DRD2HTR7HTR1AHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005066157-A1 | 3-(PYROLIDIN-3-L) INDOLES AS 5-HT6 RECEPTOR MODULATORS | SUVEN LIFE SCIENCES (IN) | 2005-07-21 | — | — | WO | disclosed |