Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 19/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6530751 | 0.94 | CYP3A4 (0.64) | HTR6CYP3A4CYP2D6HTR2AHTR1A | |
| SCHEMBL6528108 | 0.90 | HTR6 (0.60) | HTR6CYP3A4CYP2D6HTR2AHTR1A | |
| SCHEMBL6529121 | 0.90 | CYP3A4 (0.74) | HTR6CYP3A4CYP2D6HTR2AHTR1A | |
| SCHEMBL6527747 | 0.89 | HTR6 (0.62) | HTR6CYP3A4CYP2D6HTR2AHTR1A | |
| SCHEMBL6532617 | 0.84 | CYP3A4 (0.79) | HTR6CYP3A4CYP2D6 | |
| SCHEMBL6530503 | 0.84 | CYP3A4 (0.83) | HTR6CYP3A4CYP2D6 | |
| SCHEMBL6530026 | 0.82 | CYP3A4 (0.52) | HTR6CYP3A4CYP2D6HTR2ADRD2 | |
| SCHEMBL6528427 | 0.80 | CYP3A4 (0.57) | HTR6CYP3A4CYP2D6HTR2A | |
| SCHEMBL6529764 | 0.80 | HTR6 (0.61) | HTR6CYP3A4CYP2D6HTR2ADRD2 | |
| SCHEMBL6528929 | 0.79 | CYP3A4 (0.56) | HTR6CYP3A4CYP2D6HTR2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005066157-A1 | 3-(PYROLIDIN-3-L) INDOLES AS 5-HT6 RECEPTOR MODULATORS | SUVEN LIFE SCIENCES (IN) | 2005-07-21 | — | — | WO | claimed |
| WO-2005066157-A1 | 3-(PYROLIDIN-3-L) INDOLES AS 5-HT6 RECEPTOR MODULATORS | SUVEN LIFE SCIENCES (IN) | 2005-07-21 | — | — | WO | disclosed |