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Histidine

Histidine

SCHEMBL9751058

CC(C)C[C@H](N)C(=O)O.NC(=O)CC[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)O.N[C@@H](Cc1c[nH]cn1)C(=O)O

nearest known ligand 0.41

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALOX15 P16050 1/20 0.41
▸ BLM P54132 1/20 0.41
▸ PMP22 Q01453 1/20 0.41
▸ KMT2A Q03164 1/20 0.41
▸ SLC7A5 Q01650 2/20 0.39
▸ SLC1A3 P43003 3/20 0.33
▸ SLC1A2 P43004 3/20 0.33
▸ ANPEP P15144 1/20 0.33
▸ RNPEP Q9H4A4 1/20 0.33
▸ DNPEP Q9ULA0 1/20 0.33
▸ SLC1A1 P43005 2/20 0.32
▸ CYP3A4 P08684 1/20 0.32
▸ CYP1A2 P05177 2/20 0.32
▸ GRIA1 P42261 2/20 0.31
▸ GRIA2 P42262 2/20 0.31
▸ GRIA3 P42263 2/20 0.31
▸ GRIA4 P48058 2/20 0.31
▸ GRIK1 P39086 2/20 0.31
▸ GRM8 O00222 1/20 0.31
▸ GRM6 O15303 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Histidine SCHEMBL9750989 0.96 ALOX15 (0.38) ALOX15BLMPMP22KMT2ASLC7A5
Histidine SCHEMBL6534153 0.93 BLM (0.47) ALOX15BLMPMP22KMT2ASLC7A5
Histidine SCHEMBL17628714 0.93 BLM (0.47) ALOX15BLMPMP22KMT2ASLC7A5
Histidine SCHEMBL9750903 0.93 ALOX15 (0.40) ALOX15BLMPMP22KMT2ASLC7A5
Histidine SCHEMBL10379722 0.93 ALOX15 (0.40) ALOX15BLMPMP22KMT2ASLC7A5
Histidine SCHEMBL9750983 0.91 ALOX15 (0.34) ALOX15BLMPMP22KMT2ASLC7A5
Histidine SCHEMBL27980643 0.90 ALOX15 (0.40) ALOX15BLMPMP22KMT2ASLC7A5
Histidine SCHEMBL9211892 0.90 GSR (0.40) ALOX15BLMPMP22KMT2ASLC7A5
Histidine SCHEMBL9220370 0.90 GSR (0.40) ALOX15BLMPMP22KMT2ASLC7A5
Histidine SCHEMBL27806428 0.90 ALOX15 (0.38) ALOX15BLMPMP22KMT2ASLC7A5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0347435-A4 DNA SEQUENCES, RECOMBINANT DNA MOLECULES AND PROCESSES FOR PRODUCING SOLUBLE T4 PROTEINS — 1991-11-21 — — EP claimed
WO-1990004414-A1 CONJUGATES OF SOLUBLE T4 PROTEINS AND TOXINS AND METHODS FOR TREATING OR PREVENTING AIDS, ARC AND HIV INFECTION BIOGEN, INC. (US) 1990-05-03 — — WO claimed
EP-0347435-A1 DNA SEQUENCES, RECOMBINANT DNA MOLECULES AND PROCESSES FOR PRODUCING SOLUBLE T4 PROTEINS BIOGEN, INC. (US) 1989-12-27 — — EP claimed
WO-1989001940-A1 DNA SEQUENCES, RECOMBINANT DNA MOLECULES AND PROCESSES FOR PRODUCING SOLUBLE T4 PROTEINS BIOGEN, INC. (US) 1989-03-09 — — WO claimed
EP-0347435-A4 DNA SEQUENCES, RECOMBINANT DNA MOLECULES AND PROCESSES FOR PRODUCING SOLUBLE T4 PROTEINS — 1991-11-21 — — EP disclosed
EP-0378643-A4 COMBINATIONS OF SOLUBLE T4 PROTEINS AND ANTI-RETROVIRAL AGENTS AND METHODS FOR TREATING OR PREVENTING AIDS, ARC AND HIV INFECTION — 1990-12-27 — — EP disclosed
EP-0378643-A1 COMBINATIONS OF SOLUBLE T4 PROTEINS AND ANTI-RETROVIRAL AGENTS AND METHODS FOR TREATING OR PREVENTING AIDS, ARC AND HIV INFECTION BIOGEN, INC. (US) 1990-07-25 — — EP disclosed
EP-0347435-A1 DNA SEQUENCES, RECOMBINANT DNA MOLECULES AND PROCESSES FOR PRODUCING SOLUBLE T4 PROTEINS BIOGEN, INC. (US) 1989-12-27 — — EP disclosed
WO-1989011860-A1 COMBINATIONS OF SOLUBLE T4 PROTEINS AND ANTI-RETROVIRAL AGENTS AND METHODS FOR TREATING OR PREVENTING AIDS, ARC AND HIV INFECTION BIOGEN, INC. (US) 1989-12-14 — — WO disclosed
WO-1989001940-A1 DNA SEQUENCES, RECOMBINANT DNA MOLECULES AND PROCESSES FOR PRODUCING SOLUBLE T4 PROTEINS BIOGEN, INC. (US) 1989-03-09 — — WO disclosed