Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6772047 | 0.83 | KMT2A (0.58) | KMT2AMEN1ALDH1A1TDP1MAPT | |
| SCHEMBL11566827 | 0.77 | KMT2A (1.00) | KMT2AMEN1ALDH1A1LMNAPOLB | |
| SCHEMBL2039879 | 0.77 | KMT2A (1.00) | KMT2AMEN1ALDH1A1LMNAPOLB | |
| SCHEMBL30446303 | 0.77 | KMT2A (1.00) | KMT2AMEN1ALDH1A1LMNAPOLB | |
| SCHEMBL6535560 | 0.75 | LMNA (0.52) | KMT2AMEN1ALDH1A1MAPTLMNA | |
| SCHEMBL30686627 | 0.74 | ALDH1A1 (0.58) | KMT2AMEN1ALDH1A1TDP1MAPT | |
| SCHEMBL4142866 | 0.74 | ALDH1A1 (0.58) | KMT2AMEN1ALDH1A1TDP1MAPT | |
| SCHEMBL23932907 | 0.72 | VCAM1 (0.49) | KMT2AMEN1ALDH1A1POLBRAB9A | |
| SCHEMBL3919900 | 0.72 | VCAM1 (0.60) | KMT2AMEN1ALDH1A1MAPTLMNA | |
| SCHEMBL8960247 | 0.72 | POLB (0.53) | KMT2AMEN1ALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1011652-A4 | NOVEL DIARYLSULFONE NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS | UNIV THE SCIENCES IN PHILADELP (US) | 2004-12-22 | — | — | EP | disclosed |
| US-6303630-B1 | TREATING HUMAN IMMUNODEFICIENCY VIRUS INFECTION BYADMINISTERING TO A HUMAN DIARYLSULFONE COMPOUND | UNIVERSITY OF THE SCIENCES IN PHILADELPHIA | 2001-10-16 | — | — | US | disclosed |
| EP-1011652-A1 | NOVEL DIARYLSULFONE NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS | University of the Sciences in Philadelphia (US) | 2000-06-28 | — | — | EP | disclosed |
| US-6063790-A | TREATMENT OF AIDS | UNIVERSITY OF THE SCIENCES IN PHILADELPHIA (US) | 2000-05-16 | — | — | US | disclosed |
| WO-1999006037-A1 | NOVEL DIARYLSULFONE NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS | UNIVERSITY OF THE SCIENCES IN PHILADELPHIA (US) | 1999-02-11 | — | — | WO | disclosed |