Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 2/20 | 0.46 |
| ▸ | AGTR1 | P30556 | 8/20 | 0.43 |
| ▸ | MME | P08473 | 7/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6534662 | 0.93 | BRS3 (0.48) | BRS3AGTR1MMEAGTR2 | |
| SCHEMBL6534773 | 0.85 | BRS3 (0.54) | BRS3AGTR1AGTR2 | |
| SCHEMBL7315650 | 0.83 | BRS3 (0.48) | BRS3AGTR1AGTR2 | |
| SCHEMBL7322921 | 0.80 | BRS3 (0.49) | BRS3 | |
| SCHEMBL6534730 | 0.79 | BRS3 (0.52) | BRS3AGTR1AGTR2 | |
| SCHEMBL8076004 | 0.76 | BRS3 (0.46) | BRS3AGTR1AGTR2 | |
| SCHEMBL74 | 0.73 | AGTR1 (0.74) | AGTR1MMEAGTR2 | |
| SCHEMBL9205903 | 0.71 | BRS3 (0.43) | BRS3AGTR1AGTR2 | |
| SCHEMBL6534842 | 0.70 | AGTR1 (0.63) | AGTR1MMEAGTR2 | |
| SCHEMBL3460737 | 0.70 | PPARG (0.40) | BRS3AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1059843-A1 | METHOD FOR DECREASING QT DISPERSION OR INHIBITING THE PROGRESSION OF QT DISPERSION WITH AN ANGIOTENSIN II RECEPTOR ANTAGONIST | Merck & Co., Inc. (US) | 2000-12-20 | — | — | EP | claimed |
| WO-1999043210-A1 | METHOD FOR DECREASING QT DISPERSION OR INHIBITING THE PROGRESSION OF QT DISPERSION WITH AN ANGIOTENSIN II RECEPTOR ANTAGONIST | MERCK & CO., INC. (US) | 1999-09-02 | — | — | WO | claimed |
| EP-0754042-A4 | TREATMENT OF ATHEROSCLEROSIS WITH ANGIOTENSIN II RECEPTOR BLOCKING IMIDAZOLES | MERCK & CO INC (US) | 2004-06-23 | — | — | EP | disclosed |
| EP-1059843-A1 | METHOD FOR DECREASING QT DISPERSION OR INHIBITING THE PROGRESSION OF QT DISPERSION WITH AN ANGIOTENSIN II RECEPTOR ANTAGONIST | Merck & Co., Inc. (US) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999043210-A1 | METHOD FOR DECREASING QT DISPERSION OR INHIBITING THE PROGRESSION OF QT DISPERSION WITH AN ANGIOTENSIN II RECEPTOR ANTAGONIST | MERCK & CO., INC. (US) | 1999-09-02 | — | — | WO | disclosed |
| EP-0754042-A1 | TREATMENT OF ATHEROSCLEROSIS WITH ANGIOTENSIN II RECEPTOR BLOCKING IMIDAZOLES | MERCK & CO. INC. (US) | 1997-01-22 | — | — | EP | disclosed |